| http://purl.uniprot.org/citations/27760128 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27760128 | http://www.w3.org/2000/01/rdf-schema#comment | "Positive-strand RNA viruses build extensive membranous replication compartments to support replication and protect the virus from antiviral responses by the host. These viruses require host factors and various lipids to form viral replication complexes (VRCs). The VRCs built by Tomato bushy stunt virus (TBSV) are enriched with phosphatidylethanolamine (PE) through a previously unknown pathway. To unravel the mechanism of PE enrichment within the TBSV replication compartment, in this paper, the authors demonstrate that TBSV co-opts the guanosine triphosphate (GTP)-bound active form of the endosomal Rab5 small GTPase via direct interaction with the viral replication protein. Deletion of Rab5 orthologs in a yeast model host or expression of dominant negative mutants of plant Rab5 greatly decreases TBSV replication and prevents the redistribution of PE to the sites of viral replication. We also show that enrichment of PE in the viral replication compartment is assisted by actin filaments. Interestingly, the closely related Carnation Italian ringspot virus, which replicates on the boundary membrane of mitochondria, uses a similar strategy to the peroxisomal TBSV to hijack the Rab5-positive endosomes into the viral replication compartments. Altogether, usurping the GTP-Rab5-positive endosomes allows TBSV to build a PE-enriched viral replication compartment, which is needed to support peak-level replication. Thus, the Rab family of small GTPases includes critical host factors assisting VRC assembly and genesis of the viral replication compartment."xsd:string |
| http://purl.uniprot.org/citations/27760128 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pbio.2000128"xsd:string |
| http://purl.uniprot.org/citations/27760128 | http://purl.uniprot.org/core/author | "Xu K."xsd:string |
| http://purl.uniprot.org/citations/27760128 | http://purl.uniprot.org/core/author | "Nagy P.D."xsd:string |
| http://purl.uniprot.org/citations/27760128 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27760128 | http://purl.uniprot.org/core/name | "PLoS Biol"xsd:string |
| http://purl.uniprot.org/citations/27760128 | http://purl.uniprot.org/core/pages | "e2000128"xsd:string |
| http://purl.uniprot.org/citations/27760128 | http://purl.uniprot.org/core/title | "Enrichment of Phosphatidylethanolamine in Viral Replication Compartments via Co-opting the Endosomal Rab5 Small GTPase by a Positive-Strand RNA Virus."xsd:string |
| http://purl.uniprot.org/citations/27760128 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/27760128 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27760128 |
| http://purl.uniprot.org/citations/27760128 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27760128 |
| http://purl.uniprot.org/uniprot/#_P36017-mappedCitation-27760128 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27760128 |
| http://purl.uniprot.org/uniprot/#_P36018-mappedCitation-27760128 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27760128 |
| http://purl.uniprot.org/uniprot/#_P36019-mappedCitation-27760128 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27760128 |
| http://purl.uniprot.org/uniprot/P36017 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27760128 |
| http://purl.uniprot.org/uniprot/P36018 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27760128 |
| http://purl.uniprot.org/uniprot/P36019 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27760128 |