| http://purl.uniprot.org/citations/27760319 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27760319 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor-specific genomic information has the potential to guide therapeutic strategies and revolutionize patient treatment. Currently, this approach is limited by an abundance of disease-associated mutants whose biological functions and impacts on therapeutic response are uncharacterized. To begin to address this limitation, we functionally characterized nearly all (99.84%) missense mutants of MAPK1/ERK2, an essential effector of oncogenic RAS and RAF. Using this approach, we discovered rare gain- and loss-of-function ERK2 mutants found in human tumors, revealing that, in the context of this assay, mutational frequency alone cannot identify all functionally impactful mutants. Gain-of-function ERK2 mutants induced variable responses to RAF-, MEK-, and ERK-directed therapies, providing a reference for future treatment decisions. Tumor-associated mutations spatially clustered in two ERK2 effector-recruitment domains yet produced mutants with opposite phenotypes. This approach articulates an allele-characterization framework that can be scaled to meet the goals of genome-guided oncology."xsd:string |
| http://purl.uniprot.org/citations/27760319 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.09.061"xsd:string |
| http://purl.uniprot.org/citations/27760319 | http://purl.uniprot.org/core/author | "Mikkelsen T.S."xsd:string |
| http://purl.uniprot.org/citations/27760319 | http://purl.uniprot.org/core/author | "Garraway L.A."xsd:string |
| http://purl.uniprot.org/citations/27760319 | http://purl.uniprot.org/core/author | "Zhu C."xsd:string |
| http://purl.uniprot.org/citations/27760319 | http://purl.uniprot.org/core/author | "Getz G."xsd:string |
| http://purl.uniprot.org/citations/27760319 | http://purl.uniprot.org/core/author | "Cohen O."xsd:string |
| http://purl.uniprot.org/citations/27760319 | http://purl.uniprot.org/core/author | "Root D.E."xsd:string |
| http://purl.uniprot.org/citations/27760319 | http://purl.uniprot.org/core/author | "Johannessen C.M."xsd:string |
| http://purl.uniprot.org/citations/27760319 | http://purl.uniprot.org/core/author | "Piccioni F."xsd:string |
| http://purl.uniprot.org/citations/27760319 | http://purl.uniprot.org/core/author | "Burgin A.B."xsd:string |
| http://purl.uniprot.org/citations/27760319 | http://purl.uniprot.org/core/author | "Persky N.S."xsd:string |
| http://purl.uniprot.org/citations/27760319 | http://purl.uniprot.org/core/author | "Cacchiarelli D."xsd:string |
| http://purl.uniprot.org/citations/27760319 | http://purl.uniprot.org/core/author | "Kamburov A."xsd:string |
| http://purl.uniprot.org/citations/27760319 | http://purl.uniprot.org/core/author | "Andreev A."xsd:string |
| http://purl.uniprot.org/citations/27760319 | http://purl.uniprot.org/core/author | "Goetz E.M."xsd:string |
| http://purl.uniprot.org/citations/27760319 | http://purl.uniprot.org/core/author | "Bagul M."xsd:string |
| http://purl.uniprot.org/citations/27760319 | http://purl.uniprot.org/core/author | "Brenan L."xsd:string |
| http://purl.uniprot.org/citations/27760319 | http://purl.uniprot.org/core/author | "Pantel S."xsd:string |
| http://purl.uniprot.org/citations/27760319 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27760319 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/27760319 | http://purl.uniprot.org/core/pages | "1171-1183"xsd:string |
| http://purl.uniprot.org/citations/27760319 | http://purl.uniprot.org/core/title | "Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants."xsd:string |
| http://purl.uniprot.org/citations/27760319 | http://purl.uniprot.org/core/volume | "17"xsd:string |