| http://purl.uniprot.org/citations/27764807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27764807 | http://www.w3.org/2000/01/rdf-schema#comment | "Aberrant activation of c-Myc plays an important oncogenic role via regulating a series of coding and non-coding genes in acute myeloid leukemia (AML). Histone deacetylases (HDACs) can remove acetyl group from histone and regulate gene expression via changing chromatin structure. Here, we found miR-451 is abnormally down-regulated in AML patient samples; c-Myc recruits HDAC3 to form a transcriptional suppressor complex, co-localizes on the miR-451 promoter, epigenetically inhibits its transcription and finally induces its downregulation in AML. Furthermore, our in vitro and in vivo results suggest that miR-451 functions as a tumor suppressor via promoting apoptosis and suppressing malignant cell proliferation. The mechanistic study demonstrated that miR-451 directly targets YWHAZ mRNA and suppresses YWHAZ/AKT signaling in AML. Knockdown of c-Myc results in restoration of miR-451 and inhibition of YWHAZ/AKT signaling. In AML patients, low level of miR-451 is negatively correlated with high levels of c-Myc and YWHAZ, while c-Myc level is positively related to YWHAZ expression. These results suggested that c-Myc⊣miR-451⊣YWHAZ/AKT cascade might play a crucial role during leukemogenesis, and reintroduction of miR-451 could be as a potential strategy for AML therapy."xsd:string |
| http://purl.uniprot.org/citations/27764807 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.12679"xsd:string |
| http://purl.uniprot.org/citations/27764807 | http://purl.uniprot.org/core/author | "Liu B."xsd:string |
| http://purl.uniprot.org/citations/27764807 | http://purl.uniprot.org/core/author | "Song L."xsd:string |
| http://purl.uniprot.org/citations/27764807 | http://purl.uniprot.org/core/author | "Zhang X.H."xsd:string |
| http://purl.uniprot.org/citations/27764807 | http://purl.uniprot.org/core/author | "Shen C."xsd:string |
| http://purl.uniprot.org/citations/27764807 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/27764807 | http://purl.uniprot.org/core/author | "Yu J."xsd:string |
| http://purl.uniprot.org/citations/27764807 | http://purl.uniprot.org/core/author | "Yin X.L."xsd:string |
| http://purl.uniprot.org/citations/27764807 | http://purl.uniprot.org/core/author | "Su R."xsd:string |
| http://purl.uniprot.org/citations/27764807 | http://purl.uniprot.org/core/author | "Zhang J.W."xsd:string |
| http://purl.uniprot.org/citations/27764807 | http://purl.uniprot.org/core/author | "Ma Y.N."xsd:string |
| http://purl.uniprot.org/citations/27764807 | http://purl.uniprot.org/core/author | "Chen M.T."xsd:string |
| http://purl.uniprot.org/citations/27764807 | http://purl.uniprot.org/core/author | "Ning H.M."xsd:string |
| http://purl.uniprot.org/citations/27764807 | http://purl.uniprot.org/core/author | "Zhao H.L."xsd:string |
| http://purl.uniprot.org/citations/27764807 | http://purl.uniprot.org/core/author | "Gong J.N."xsd:string |
| http://purl.uniprot.org/citations/27764807 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27764807 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/27764807 | http://purl.uniprot.org/core/pages | "77430-77443"xsd:string |
| http://purl.uniprot.org/citations/27764807 | http://purl.uniprot.org/core/title | "c-Myc suppresses miR-451⊣YWTAZ/AKT axis via recruiting HDAC3 in acute myeloid leukemia."xsd:string |
| http://purl.uniprot.org/citations/27764807 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27764807 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27764807 |
| http://purl.uniprot.org/citations/27764807 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27764807 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-27764807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27764807 |