| http://purl.uniprot.org/citations/27766861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27766861 | http://www.w3.org/2000/01/rdf-schema#comment | "Methyl 9-anilinothiazolo[5,4-f]quinazoline-2-carbimidates 1 (EHT 5372) and 2 (EHT 1610) are strong inhibitors of DYRK's family kinases. The crystal structures of the complex revealed a noncanonical binding mode of compounds 1 and 2 in DYRK2, explaining the remarkable selectivity and potency of these inhibitors. The structural data and comparison presented here provide therefore a template for further improvement of this inhibitor class and for the development of novel inhibitors selectively targeting DYRK kinases."xsd:string |
| http://purl.uniprot.org/citations/27766861 | http://purl.org/dc/terms/identifier | "doi:10.1021/acs.jmedchem.6b01083"xsd:string |
| http://purl.uniprot.org/citations/27766861 | http://purl.uniprot.org/core/author | "Schroder M."xsd:string |
| http://purl.uniprot.org/citations/27766861 | http://purl.uniprot.org/core/author | "Knapp S."xsd:string |
| http://purl.uniprot.org/citations/27766861 | http://purl.uniprot.org/core/author | "Bonnet P."xsd:string |
| http://purl.uniprot.org/citations/27766861 | http://purl.uniprot.org/core/author | "Besson T."xsd:string |
| http://purl.uniprot.org/citations/27766861 | http://purl.uniprot.org/core/author | "Chaikuad A."xsd:string |
| http://purl.uniprot.org/citations/27766861 | http://purl.uniprot.org/core/author | "Leblond B."xsd:string |
| http://purl.uniprot.org/citations/27766861 | http://purl.uniprot.org/core/author | "Desire L."xsd:string |
| http://purl.uniprot.org/citations/27766861 | http://purl.uniprot.org/core/author | "Casagrande A.S."xsd:string |
| http://purl.uniprot.org/citations/27766861 | http://purl.uniprot.org/core/author | "Foucourt A."xsd:string |
| http://purl.uniprot.org/citations/27766861 | http://purl.uniprot.org/core/author | "Diharce J."xsd:string |
| http://purl.uniprot.org/citations/27766861 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27766861 | http://purl.uniprot.org/core/name | "J Med Chem"xsd:string |
| http://purl.uniprot.org/citations/27766861 | http://purl.uniprot.org/core/pages | "10315-10321"xsd:string |
| http://purl.uniprot.org/citations/27766861 | http://purl.uniprot.org/core/title | "An Unusual Binding Model of the Methyl 9-Anilinothiazolo[5,4-f] quinazoline-2-carbimidates (EHT 1610 and EHT 5372) Confers High Selectivity for Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases."xsd:string |
| http://purl.uniprot.org/citations/27766861 | http://purl.uniprot.org/core/volume | "59"xsd:string |
| http://purl.uniprot.org/citations/27766861 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27766861 |
| http://purl.uniprot.org/citations/27766861 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27766861 |
| http://purl.uniprot.org/uniprot/#_Q92630-mappedCitation-27766861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27766861 |
| http://purl.uniprot.org/uniprot/Q92630 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27766861 |