http://purl.uniprot.org/citations/27768223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/27768223 | http://www.w3.org/2000/01/rdf-schema#comment | "PurposeCofilin 1 is a type of cytoskeletal protein. The overexpression of this gene has been regarded to hold a special relationship with the development and progress of some cancers. However, the detailed position of Cofilin 1 in human bladder cancer has not been investigated intensively.MethodsIn this study, we mainly explored the relationship between human bladder cancer and the expression of Cofilin 1. The expression of Cofilin 1 in bladder cancer tissues and paracancerous tissues of patients was evaluated with quantitative polymerase chain reaction, Western blot, and immunohistochemical staining. Downregulation of Cofilin 1 expression model was established with siRNA in human RT4 bladder cancer cell line, and the changing cell viability was analyzed to determine the role of Cofilin 1 in human bladder cancer.ResultsOur results showed that the expression of Cofilin 1 was much higher in both RNA level and protein level in human bladder cancer tissues than paracancerous tissues for 3 patients. Downregulation of Cofilin 1 expression could inhibit cell proliferation, cell migration, cell adhesion, and colony formation ability, and increase the percentage of cell apoptosis in RT4 cells.ConclusionsOur study indicates that Cofilin 1 holds an important position in the development and progression of human bladder cancer, and this gene might become a novel target in the diagnosis and treatment of human bladder cancer."xsd:string |
http://purl.uniprot.org/citations/27768223 | http://purl.org/dc/terms/identifier | "doi:10.5301/tj.5000569"xsd:string |
http://purl.uniprot.org/citations/27768223 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
http://purl.uniprot.org/citations/27768223 | http://purl.uniprot.org/core/author | "He F."xsd:string |
http://purl.uniprot.org/citations/27768223 | http://purl.uniprot.org/core/author | "Fu H."xsd:string |
http://purl.uniprot.org/citations/27768223 | http://purl.uniprot.org/core/author | "Wu D."xsd:string |
http://purl.uniprot.org/citations/27768223 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
http://purl.uniprot.org/citations/27768223 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
http://purl.uniprot.org/citations/27768223 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
http://purl.uniprot.org/citations/27768223 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
http://purl.uniprot.org/citations/27768223 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
http://purl.uniprot.org/citations/27768223 | http://purl.uniprot.org/core/name | "Tumori"xsd:string |
http://purl.uniprot.org/citations/27768223 | http://purl.uniprot.org/core/pages | "537-542"xsd:string |
http://purl.uniprot.org/citations/27768223 | http://purl.uniprot.org/core/title | "Study on the significance of Cofilin 1 overexpression in human bladder cancer."xsd:string |
http://purl.uniprot.org/citations/27768223 | http://purl.uniprot.org/core/volume | "103"xsd:string |
http://purl.uniprot.org/citations/27768223 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27768223 |
http://purl.uniprot.org/citations/27768223 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27768223 |
http://purl.uniprot.org/uniprot/#_B4E112-mappedCitation-27768223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27768223 |
http://purl.uniprot.org/uniprot/#_G3V1A4-mappedCitation-27768223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27768223 |
http://purl.uniprot.org/uniprot/#_P23528-mappedCitation-27768223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27768223 |
http://purl.uniprot.org/uniprot/#_V9HWI5-mappedCitation-27768223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27768223 |
http://purl.uniprot.org/uniprot/P23528 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27768223 |
http://purl.uniprot.org/uniprot/V9HWI5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27768223 |
http://purl.uniprot.org/uniprot/B4E112 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27768223 |