| http://purl.uniprot.org/citations/27768595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27768595 | http://www.w3.org/2000/01/rdf-schema#comment | "One of the features of cellular senescence is the activity of senescence-associated-β-galactosidase (SA-β-gal). The main purpose of this study was to evaluate this marker of senescence in aging neurons. We found that cortical neurons exhibited noticeable SA-β-gal activity quite early in culture. Many SA-β-gal-positive neurons were negative for another canonical marker of senescence, namely, double-strand DNA breaks (DSBs). Moreover, DDR signalling triggered by low doses of doxorubicin did not accelerate the appearance of neuronal SA-β-gal. In vivo, we observed pronounced induction of SA-β-gal activity in the hippocampus of 24-month-old mice, which is consistent with previous findings and supports the view that at this advanced age neurons developed a senescence-like phenotype. Surprisingly however, relatively high SA-β-gal activity, probably unrelated to the senescence process, was also observed in much younger, 3-month-old mice. In conclusion, we propose that SA-β-gal activity in neurons cannot be attributed uniquely to cell senescence either in vitro or in vivo. Additionally, we showed induction of REST protein in aging neurons in long-term culture and we propose that REST could be a marker of neuronal senescence in vitro."xsd:string |
| http://purl.uniprot.org/citations/27768595 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.12752"xsd:string |
| http://purl.uniprot.org/citations/27768595 | http://purl.uniprot.org/core/author | "Wysocka A."xsd:string |
| http://purl.uniprot.org/citations/27768595 | http://purl.uniprot.org/core/author | "Piechota M."xsd:string |
| http://purl.uniprot.org/citations/27768595 | http://purl.uniprot.org/core/author | "Sikora E."xsd:string |
| http://purl.uniprot.org/citations/27768595 | http://purl.uniprot.org/core/author | "Radwanska K."xsd:string |
| http://purl.uniprot.org/citations/27768595 | http://purl.uniprot.org/core/author | "Sliwinska M.A."xsd:string |
| http://purl.uniprot.org/citations/27768595 | http://purl.uniprot.org/core/author | "Sunderland P."xsd:string |
| http://purl.uniprot.org/citations/27768595 | http://purl.uniprot.org/core/author | "Nalberczak M."xsd:string |
| http://purl.uniprot.org/citations/27768595 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27768595 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/27768595 | http://purl.uniprot.org/core/pages | "81099-81109"xsd:string |
| http://purl.uniprot.org/citations/27768595 | http://purl.uniprot.org/core/title | "Is senescence-associated beta-galactosidase a marker of neuronal senescence?"xsd:string |
| http://purl.uniprot.org/citations/27768595 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27768595 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27768595 |
| http://purl.uniprot.org/citations/27768595 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27768595 |
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| http://purl.uniprot.org/uniprot/#_Q3TAW7-mappedCitation-27768595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27768595 |
| http://purl.uniprot.org/uniprot/#_Q8K131-mappedCitation-27768595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27768595 |
| http://purl.uniprot.org/uniprot/#_Q8C847-mappedCitation-27768595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27768595 |
| http://purl.uniprot.org/uniprot/#_Q8C659-mappedCitation-27768595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27768595 |
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