| http://purl.uniprot.org/citations/27769050 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27769050 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously demonstrated that the activation of α9-nicotinic acetylcholine receptor (α9-nAchR) signaling by smoking promotes breast cancer formation. To investigate the downstream signaling molecules involved in α9-nAChR-induced breast tumorigenesis, we used real-time polymerase chain reactions and Western blotting to assess expression of protein phosphatase Mg2+/Mn2+ dependent 1F (PPM1F), a Ser/Thr protein phosphatase, in human breast cancer samples (n=167). Additionally, stable PPM1F-knockdown and -overexpressing cell lines were established to evaluate the function of PPM1F. The phosphatase activity of PPM1F in nicotine-treated cells was assessed through Western blotting, confocal microscopy, and fluorescence resonance energy transfer. Higher levels of PPM1F were detected in the breast cancer tissues of heavy smokers (n=7, 12.8-fold) greater than of non-smokers (n= 28, 6.3-fold) (**p=0.01). In vitro, nicotine induced PPM1F expression, whereas α9-nAChR knockdown reduced the protein expression of PPM1F. A series of biochemical experiments using nicotine-treated cells suggested that the dephosphorylation of p53 (Ser-20) and BAX (Ser-184) by PPM1F is a critical posttranslational modification, as observed in breast cancer patients who were heavy smokers. These observations indicate that PPM1F may be a mediator downstream of α9-nAChR that activates smoking-induced carcinogenic signals. Thus, PPM1F expression could be used for prognostic diagnosis or inhibited for cancer prevention and therapy."xsd:string |
| http://purl.uniprot.org/citations/27769050 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.12717"xsd:string |
| http://purl.uniprot.org/citations/27769050 | http://purl.uniprot.org/core/author | "Chang C.H."xsd:string |
| http://purl.uniprot.org/citations/27769050 | http://purl.uniprot.org/core/author | "Huang C.C."xsd:string |
| http://purl.uniprot.org/citations/27769050 | http://purl.uniprot.org/core/author | "Chang H.W."xsd:string |
| http://purl.uniprot.org/citations/27769050 | http://purl.uniprot.org/core/author | "Lin Y.C."xsd:string |
| http://purl.uniprot.org/citations/27769050 | http://purl.uniprot.org/core/author | "Ho Y.S."xsd:string |
| http://purl.uniprot.org/citations/27769050 | http://purl.uniprot.org/core/author | "Wu C.H."xsd:string |
| http://purl.uniprot.org/citations/27769050 | http://purl.uniprot.org/core/author | "Chen L.C."xsd:string |
| http://purl.uniprot.org/citations/27769050 | http://purl.uniprot.org/core/author | "Tu S.H."xsd:string |
| http://purl.uniprot.org/citations/27769050 | http://purl.uniprot.org/core/author | "Yang P.S."xsd:string |
| http://purl.uniprot.org/citations/27769050 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27769050 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/27769050 | http://purl.uniprot.org/core/pages | "77516-77531"xsd:string |
| http://purl.uniprot.org/citations/27769050 | http://purl.uniprot.org/core/title | "Protein phosphatase Mg2+/Mn2+ dependent 1F promotes smoking-induced breast cancer by inactivating phosphorylated-p53-induced signals."xsd:string |
| http://purl.uniprot.org/citations/27769050 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27769050 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27769050 |
| http://purl.uniprot.org/citations/27769050 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27769050 |
| http://purl.uniprot.org/uniprot/#_A0M8Q2-mappedCitation-27769050 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27769050 |
| http://purl.uniprot.org/uniprot/#_A8MX49-mappedCitation-27769050 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27769050 |
| http://purl.uniprot.org/uniprot/#_B3KX06-mappedCitation-27769050 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27769050 |
| http://purl.uniprot.org/uniprot/#_B5MCT7-mappedCitation-27769050 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27769050 |
| http://purl.uniprot.org/uniprot/#_P04637-mappedCitation-27769050 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27769050 |
| http://purl.uniprot.org/uniprot/#_P49593-mappedCitation-27769050 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27769050 |