| http://purl.uniprot.org/citations/27775703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27775703 | http://www.w3.org/2000/01/rdf-schema#comment | "Stabilization of mutant p53 (mutp53) in tumours greatly contributes to malignant progression. However, little is known about the underlying mechanisms and therapeutic approaches to destabilize mutp53. Here, through high-throughput screening we identify statins, cholesterol-lowering drugs, as degradation inducers for conformational or misfolded p53 mutants with minimal effects on wild-type p53 (wtp53) and DNA contact mutants. Statins preferentially suppress mutp53-expressing cancer cell growth. Specific reduction of mevalonate-5-phosphate by statins or mevalonate kinase knockdown induces CHIP ubiquitin ligase-mediated nuclear export, ubiquitylation, and degradation of mutp53 by impairing interaction of mutp53 with DNAJA1, a Hsp40 family member. Knockdown of DNAJA1 also induces CHIP-mediated mutp53 degradation, while its overexpression antagonizes statin-induced mutp53 degradation. Our study reveals that DNAJA1 controls the fate of misfolded mutp53, provides insights into potential strategies to deplete mutp53 through the mevalonate pathway-DNAJA1 axis, and highlights the significance of p53 status in impacting statins' efficacy on cancer therapy."xsd:string |
| http://purl.uniprot.org/citations/27775703 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb3427"xsd:string |
| http://purl.uniprot.org/citations/27775703 | http://purl.uniprot.org/core/author | "Roy A."xsd:string |
| http://purl.uniprot.org/citations/27775703 | http://purl.uniprot.org/core/author | "Iwakuma T."xsd:string |
| http://purl.uniprot.org/citations/27775703 | http://purl.uniprot.org/core/author | "Iyer S.V."xsd:string |
| http://purl.uniprot.org/citations/27775703 | http://purl.uniprot.org/core/author | "Parrales A."xsd:string |
| http://purl.uniprot.org/citations/27775703 | http://purl.uniprot.org/core/author | "Ranjan A."xsd:string |
| http://purl.uniprot.org/citations/27775703 | http://purl.uniprot.org/core/author | "Padhye S."xsd:string |
| http://purl.uniprot.org/citations/27775703 | http://purl.uniprot.org/core/author | "Weir S.J."xsd:string |
| http://purl.uniprot.org/citations/27775703 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27775703 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/27775703 | http://purl.uniprot.org/core/pages | "1233-1243"xsd:string |
| http://purl.uniprot.org/citations/27775703 | http://purl.uniprot.org/core/title | "DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway."xsd:string |
| http://purl.uniprot.org/citations/27775703 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/27775703 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27775703 |
| http://purl.uniprot.org/citations/27775703 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27775703 |
| http://purl.uniprot.org/uniprot/#_A0A0A0U7X4-mappedCitation-27775703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27775703 |
| http://purl.uniprot.org/uniprot/#_A0A0M4B4Y9-mappedCitation-27775703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27775703 |
| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-27775703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27775703 |
| http://purl.uniprot.org/uniprot/#_A0A0C4KX50-mappedCitation-27775703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27775703 |
| http://purl.uniprot.org/uniprot/#_A0A0C4L134-mappedCitation-27775703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27775703 |
| http://purl.uniprot.org/uniprot/#_A0A087X1Q1-mappedCitation-27775703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27775703 |
| http://purl.uniprot.org/uniprot/#_A0A218MJE5-mappedCitation-27775703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27775703 |
| http://purl.uniprot.org/uniprot/#_A0A087WT22-mappedCitation-27775703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27775703 |