| http://purl.uniprot.org/citations/27776110 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27776110 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27776110 | http://www.w3.org/2000/01/rdf-schema#comment | "TBK1 is essential for interferon-β (IFN-β) production and innate antiviral immunity. Here we identified the T cell anergy-related E3 ubiquitin ligase RNF128 as a positive regulator of TBK1 activation. RNF128 directly interacted with TBK1 through its protease-associated (PA) domain and catalyzed the K63-linked polyubiquitination of TBK1, which led to TBK1 activation, IRF3 activation and IFN-β production. Deficiency of RNF128 expression attenuated IRF3 activation, IFN-β production and innate antiviral immune responses to RNA and DNA viruses, in vitro and in vivo. Our study identified RNF128 as an E3 ligase for K63-linked ubiquitination and activation of TBK1 and delineated a previously unrecognized function for RNF128."xsd:string |
| http://purl.uniprot.org/citations/27776110 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.3588"xsd:string |
| http://purl.uniprot.org/citations/27776110 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.3588"xsd:string |
| http://purl.uniprot.org/citations/27776110 | http://purl.uniprot.org/core/author | "Gao C."xsd:string |
| http://purl.uniprot.org/citations/27776110 | http://purl.uniprot.org/core/author | "Gao C."xsd:string |
| http://purl.uniprot.org/citations/27776110 | http://purl.uniprot.org/core/author | "Liu B."xsd:string |
| http://purl.uniprot.org/citations/27776110 | http://purl.uniprot.org/core/author | "Liu B."xsd:string |
| http://purl.uniprot.org/citations/27776110 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/27776110 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/27776110 | http://purl.uniprot.org/core/author | "Song G."xsd:string |
| http://purl.uniprot.org/citations/27776110 | http://purl.uniprot.org/core/author | "Song G."xsd:string |
| http://purl.uniprot.org/citations/27776110 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/27776110 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/27776110 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/27776110 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/27776110 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/27776110 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/27776110 | http://purl.uniprot.org/core/author | "Zhao K."xsd:string |
| http://purl.uniprot.org/citations/27776110 | http://purl.uniprot.org/core/author | "Zhao K."xsd:string |
| http://purl.uniprot.org/citations/27776110 | http://purl.uniprot.org/core/author | "Jiang G."xsd:string |
| http://purl.uniprot.org/citations/27776110 | http://purl.uniprot.org/core/author | "Jiang G."xsd:string |
| http://purl.uniprot.org/citations/27776110 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27776110 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |