| http://purl.uniprot.org/citations/27780854 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27780854 | http://www.w3.org/2000/01/rdf-schema#comment | "Purpose: T-cell lymphomas are a molecularly heterogeneous group of non-Hodgkin lymphomas (NHL) that account for a disproportionate number of NHL disease-related deaths due to their inherent and acquired resistance to standard multiagent chemotherapy regimens. Despite their molecular heterogeneity and frequent loss of various T cell-specific receptors, the T-cell antigen receptor is retained in the majority of these lymphomas. As T-cell receptor (TCR) engagement activates a number of signaling pathways and transcription factors that regulate T-cell growth and survival, we examined the TCR's role in mediating resistance to chemotherapy.Experimental Design: Genetic and pharmacologic strategies were utilized to determine the contribution of tyrosine kinases and transcription factors activated in conventional T cells following TCR engagement in acquired chemotherapy resistance in primary T-cell lymphoma cells and patient-derived cell lines.Results: Here, we report that TCR signaling activates a signaling axis that includes ITK, NF-κB, and GATA-3 and promotes chemotherapy resistance.Conclusions: These observations have significant therapeutic implications, as pharmacologic inhibition of ITK prevented the activation of this signaling axis and overcame chemotherapy resistance. Clin Cancer Res; 23(10); 2506-15. ©2016 AACR."xsd:string |
| http://purl.uniprot.org/citations/27780854 | http://purl.org/dc/terms/identifier | "doi:10.1158/1078-0432.ccr-16-1996"xsd:string |
| http://purl.uniprot.org/citations/27780854 | http://purl.uniprot.org/core/author | "Fujiwara H."xsd:string |
| http://purl.uniprot.org/citations/27780854 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/27780854 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/27780854 | http://purl.uniprot.org/core/author | "Wilcox R.A."xsd:string |
| http://purl.uniprot.org/citations/27780854 | http://purl.uniprot.org/core/author | "Lim M.S."xsd:string |
| http://purl.uniprot.org/citations/27780854 | http://purl.uniprot.org/core/author | "Chowdhury P."xsd:string |
| http://purl.uniprot.org/citations/27780854 | http://purl.uniprot.org/core/author | "Murga-Zamalloa C."xsd:string |
| http://purl.uniprot.org/citations/27780854 | http://purl.uniprot.org/core/author | "Suemori K."xsd:string |
| http://purl.uniprot.org/citations/27780854 | http://purl.uniprot.org/core/author | "Beyersdorf N."xsd:string |
| http://purl.uniprot.org/citations/27780854 | http://purl.uniprot.org/core/author | "Bailey N.G."xsd:string |
| http://purl.uniprot.org/citations/27780854 | http://purl.uniprot.org/core/author | "Hristov A.C."xsd:string |
| http://purl.uniprot.org/citations/27780854 | http://purl.uniprot.org/core/author | "Polk A."xsd:string |
| http://purl.uniprot.org/citations/27780854 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27780854 | http://purl.uniprot.org/core/name | "Clin Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/27780854 | http://purl.uniprot.org/core/pages | "2506-2515"xsd:string |
| http://purl.uniprot.org/citations/27780854 | http://purl.uniprot.org/core/title | "T-cell Receptor Signaling Activates an ITK/NF-kappaB/GATA-3 axis in T-cell Lymphomas Facilitating Resistance to Chemotherapy."xsd:string |
| http://purl.uniprot.org/citations/27780854 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/27780854 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27780854 |
| http://purl.uniprot.org/citations/27780854 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27780854 |
| http://purl.uniprot.org/uniprot/#_B4E110-mappedCitation-27780854 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27780854 |
| http://purl.uniprot.org/uniprot/#_B4DP71-mappedCitation-27780854 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27780854 |
| http://purl.uniprot.org/uniprot/#_P23771-mappedCitation-27780854 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27780854 |