| http://purl.uniprot.org/citations/27783938 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27783938 | http://www.w3.org/2000/01/rdf-schema#comment | "Vitamin D has multiple roles, including the regulation of bone and calcium homeostasis. Deficiency of 25-hydroxyvitamin D, the major circulating form of vitamin D, is associated with an increased risk of age-related chronic diseases, including Alzheimer's disease, Parkinson's disease, cognitive impairment, and cancer. In this study, we utilized Caenorhabditis elegans to examine the mechanism by which vitamin D influences aging. We found that vitamin-D3-induced lifespan extension requires the stress response pathway genes skn-1, ire-1, and xbp-1. Vitamin D3 (D3) induced expression of SKN-1 target genes but not canonical targets of XBP-1. D3 suppressed an important molecular pathology of aging, that of widespread protein insolubility, and prevented toxicity caused by human β-amyloid. Our observation that D3 improves protein homeostasis and slows aging highlights the importance of maintaining appropriate vitamin D serum levels and may explain why such a wide variety of human age-related diseases are associated with vitamin D deficiency."xsd:string |
| http://purl.uniprot.org/citations/27783938 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.09.086"xsd:string |
| http://purl.uniprot.org/citations/27783938 | http://purl.uniprot.org/core/author | "Gibson B.W."xsd:string |
| http://purl.uniprot.org/citations/27783938 | http://purl.uniprot.org/core/author | "Schilling B."xsd:string |
| http://purl.uniprot.org/citations/27783938 | http://purl.uniprot.org/core/author | "Sorensen D.J."xsd:string |
| http://purl.uniprot.org/citations/27783938 | http://purl.uniprot.org/core/author | "Dumas K.J."xsd:string |
| http://purl.uniprot.org/citations/27783938 | http://purl.uniprot.org/core/author | "Brem R.B."xsd:string |
| http://purl.uniprot.org/citations/27783938 | http://purl.uniprot.org/core/author | "Davis S."xsd:string |
| http://purl.uniprot.org/citations/27783938 | http://purl.uniprot.org/core/author | "Lithgow G.J."xsd:string |
| http://purl.uniprot.org/citations/27783938 | http://purl.uniprot.org/core/author | "Lucanic M."xsd:string |
| http://purl.uniprot.org/citations/27783938 | http://purl.uniprot.org/core/author | "Ramanathan A."xsd:string |
| http://purl.uniprot.org/citations/27783938 | http://purl.uniprot.org/core/author | "Melov S."xsd:string |
| http://purl.uniprot.org/citations/27783938 | http://purl.uniprot.org/core/author | "Bhaumik D."xsd:string |
| http://purl.uniprot.org/citations/27783938 | http://purl.uniprot.org/core/author | "Oron T.R."xsd:string |
| http://purl.uniprot.org/citations/27783938 | http://purl.uniprot.org/core/author | "Mark K.A."xsd:string |
| http://purl.uniprot.org/citations/27783938 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27783938 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/27783938 | http://purl.uniprot.org/core/pages | "1227-1237"xsd:string |
| http://purl.uniprot.org/citations/27783938 | http://purl.uniprot.org/core/title | "Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1."xsd:string |
| http://purl.uniprot.org/citations/27783938 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/27783938 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27783938 |
| http://purl.uniprot.org/citations/27783938 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27783938 |
| http://purl.uniprot.org/uniprot/#_P34707-mappedCitation-27783938 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27783938 |
| http://purl.uniprot.org/uniprot/#_E5QCG0-mappedCitation-27783938 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27783938 |