| http://purl.uniprot.org/citations/27783949 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27783949 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic hepatitis B, C, and D virus (HBV, HCV, and HDV) infections are the leading causes of liver disease and cancer worldwide. Recently, the solute carrier and sodium taurocholate co-transporter NTCP has been identified as a receptor for HBV and HDV. Here, we uncover NTCP as a host factor regulating HCV infection. Using gain- and loss-of-function studies, we show that NTCP mediates HCV infection of hepatocytes and is relevant for cell-to-cell transmission. NTCP regulates HCV infection by augmenting the bile-acid-mediated repression of interferon-stimulated genes (ISGs), including IFITM3. In conclusion, our results uncover NTCP as a mediator of innate antiviral immune responses in the liver, and they establish a role for NTCP in the infection process of multiple viruses via distinct mechanisms. Collectively, our findings suggest a role for solute carriers in the regulation of innate antiviral responses, and they have potential implications for virus-host interactions and antiviral therapies."xsd:string |
| http://purl.uniprot.org/citations/27783949 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.09.084"xsd:string |
| http://purl.uniprot.org/citations/27783949 | http://purl.uniprot.org/core/author | "Schuster C."xsd:string |
| http://purl.uniprot.org/citations/27783949 | http://purl.uniprot.org/core/author | "Bach C."xsd:string |
| http://purl.uniprot.org/citations/27783949 | http://purl.uniprot.org/core/author | "Xiao F."xsd:string |
| http://purl.uniprot.org/citations/27783949 | http://purl.uniprot.org/core/author | "Sureau C."xsd:string |
| http://purl.uniprot.org/citations/27783949 | http://purl.uniprot.org/core/author | "Cosset F.L."xsd:string |
| http://purl.uniprot.org/citations/27783949 | http://purl.uniprot.org/core/author | "McKeating J.A."xsd:string |
| http://purl.uniprot.org/citations/27783949 | http://purl.uniprot.org/core/author | "Baumert T.F."xsd:string |
| http://purl.uniprot.org/citations/27783949 | http://purl.uniprot.org/core/author | "Zeisel M.B."xsd:string |
| http://purl.uniprot.org/citations/27783949 | http://purl.uniprot.org/core/author | "Gaudin R."xsd:string |
| http://purl.uniprot.org/citations/27783949 | http://purl.uniprot.org/core/author | "Heydmann L."xsd:string |
| http://purl.uniprot.org/citations/27783949 | http://purl.uniprot.org/core/author | "Pessaux P."xsd:string |
| http://purl.uniprot.org/citations/27783949 | http://purl.uniprot.org/core/author | "Thumann C."xsd:string |
| http://purl.uniprot.org/citations/27783949 | http://purl.uniprot.org/core/author | "Zona L."xsd:string |
| http://purl.uniprot.org/citations/27783949 | http://purl.uniprot.org/core/author | "Colpitts C.C."xsd:string |
| http://purl.uniprot.org/citations/27783949 | http://purl.uniprot.org/core/author | "Hoshida Y."xsd:string |
| http://purl.uniprot.org/citations/27783949 | http://purl.uniprot.org/core/author | "Verrier E.R."xsd:string |
| http://purl.uniprot.org/citations/27783949 | http://purl.uniprot.org/core/author | "Crouchet E."xsd:string |
| http://purl.uniprot.org/citations/27783949 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27783949 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/27783949 | http://purl.uniprot.org/core/pages | "1357-1368"xsd:string |
| http://purl.uniprot.org/citations/27783949 | http://purl.uniprot.org/core/title | "Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes."xsd:string |
| http://purl.uniprot.org/citations/27783949 | http://purl.uniprot.org/core/volume | "17"xsd:string |