| http://purl.uniprot.org/citations/27786273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27786273 | http://www.w3.org/2000/01/rdf-schema#comment | "Cross-linkage of the high-affinity immunoglobulin E (IgE) receptor (FcɛRI) on mast cells by antigen ligation has a critical role in the pathology of IgE-dependent allergic disorders, such as anaphylaxis and asthma. Restraint of intracellular signal transduction pathways that promote release of mast cell-derived pro-inflammatory mediators is necessary to dampen activation and restore homoeostasis. Here we show that the ligase Nedd4-2 and the adaptor Ndfip1 (Nedd4 family interacting protein 1) limit the intensity and duration of IgE-FcɛRI-induced positive signal transduction by ubiquitinating phosphorylated Syk, a tyrosine kinase that is indispensable for downstream FcɛRI signalosome activity. Importantly, loss of Nedd4-2 or Ndfip1 in mast cells results in exacerbated and prolonged IgE-mediated cutaneous anaphylaxis in vivo. Our findings reveal an important negative regulatory function for Nedd4-2 and Ndfip1 in IgE-dependent mast cell activity."xsd:string |
| http://purl.uniprot.org/citations/27786273 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms13198"xsd:string |
| http://purl.uniprot.org/citations/27786273 | http://purl.uniprot.org/core/author | "Kumar S."xsd:string |
| http://purl.uniprot.org/citations/27786273 | http://purl.uniprot.org/core/author | "Lopez A.F."xsd:string |
| http://purl.uniprot.org/citations/27786273 | http://purl.uniprot.org/core/author | "Galli S.J."xsd:string |
| http://purl.uniprot.org/citations/27786273 | http://purl.uniprot.org/core/author | "Yip K.H."xsd:string |
| http://purl.uniprot.org/citations/27786273 | http://purl.uniprot.org/core/author | "Grimbaldeston M.A."xsd:string |
| http://purl.uniprot.org/citations/27786273 | http://purl.uniprot.org/core/author | "Kolesnikoff N."xsd:string |
| http://purl.uniprot.org/citations/27786273 | http://purl.uniprot.org/core/author | "Biggs L."xsd:string |
| http://purl.uniprot.org/citations/27786273 | http://purl.uniprot.org/core/author | "Hauschild N."xsd:string |
| http://purl.uniprot.org/citations/27786273 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27786273 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/27786273 | http://purl.uniprot.org/core/pages | "13198"xsd:string |
| http://purl.uniprot.org/citations/27786273 | http://purl.uniprot.org/core/title | "The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation."xsd:string |
| http://purl.uniprot.org/citations/27786273 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/27786273 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27786273 |
| http://purl.uniprot.org/citations/27786273 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27786273 |
| http://purl.uniprot.org/uniprot/#_A0A494B953-mappedCitation-27786273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27786273 |
| http://purl.uniprot.org/uniprot/#_A0A286YDV4-mappedCitation-27786273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27786273 |
| http://purl.uniprot.org/uniprot/#_A0A571BG49-mappedCitation-27786273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27786273 |
| http://purl.uniprot.org/uniprot/#_A0A494B9F0-mappedCitation-27786273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27786273 |
| http://purl.uniprot.org/uniprot/#_A0A494B9F5-mappedCitation-27786273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27786273 |
| http://purl.uniprot.org/uniprot/#_A0A494B9L5-mappedCitation-27786273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27786273 |
| http://purl.uniprot.org/uniprot/#_A0A494BA39-mappedCitation-27786273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27786273 |