| http://purl.uniprot.org/citations/27791083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27791083 | http://www.w3.org/2000/01/rdf-schema#comment | "Inositol-based signaling molecules are central eukaryotic messengers and include the highly phosphorylated, diffusible inositol polyphosphates (InsPs) and inositol pyrophosphates (PP-InsPs). Despite the essential cellular regulatory functions of InsPs and PP-InsPs (including telomere maintenance, phosphate sensing, cell migration, and insulin secretion), the majority of their protein targets remain unknown. Here, the development of InsP and PP-InsP affinity reagents is described to comprehensively annotate the interactome of these messenger molecules. By using the reagents as bait, >150 putative protein targets were discovered from a eukaryotic cell lysate (Saccharomyces cerevisiae). Gene Ontology analysis of the binding partners revealed a significant overrepresentation of proteins involved in nucleotide metabolism, glucose metabolism, ribosome biogenesis, and phosphorylation-based signal transduction pathways. Notably, we isolated and characterized additional substrates of protein pyrophosphorylation, a unique posttranslational modification mediated by the PP-InsPs. Our findings not only demonstrate that the PP-InsPs provide a central line of communication between signaling and metabolic networks, but also highlight the unusual ability of these molecules to access two distinct modes of action."xsd:string |
| http://purl.uniprot.org/citations/27791083 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1606853113"xsd:string |
| http://purl.uniprot.org/citations/27791083 | http://purl.uniprot.org/core/author | "Wu M."xsd:string |
| http://purl.uniprot.org/citations/27791083 | http://purl.uniprot.org/core/author | "Perlman D.H."xsd:string |
| http://purl.uniprot.org/citations/27791083 | http://purl.uniprot.org/core/author | "Resnick A.C."xsd:string |
| http://purl.uniprot.org/citations/27791083 | http://purl.uniprot.org/core/author | "Chong L.S."xsd:string |
| http://purl.uniprot.org/citations/27791083 | http://purl.uniprot.org/core/author | "Fiedler D."xsd:string |
| http://purl.uniprot.org/citations/27791083 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27791083 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/27791083 | http://purl.uniprot.org/core/pages | "E6757-E6765"xsd:string |
| http://purl.uniprot.org/citations/27791083 | http://purl.uniprot.org/core/title | "Inositol polyphosphates intersect with signaling and metabolic networks via two distinct mechanisms."xsd:string |
| http://purl.uniprot.org/citations/27791083 | http://purl.uniprot.org/core/volume | "113"xsd:string |
| http://purl.uniprot.org/citations/27791083 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27791083 |
| http://purl.uniprot.org/citations/27791083 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27791083 |
| http://purl.uniprot.org/uniprot/#_P53927-mappedCitation-27791083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27791083 |
| http://purl.uniprot.org/uniprot/#_Q06685-mappedCitation-27791083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27791083 |
| http://purl.uniprot.org/uniprot/#_Q03532-mappedCitation-27791083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27791083 |
| http://purl.uniprot.org/uniprot/#_P00950-mappedCitation-27791083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27791083 |
| http://purl.uniprot.org/uniprot/#_P17442-mappedCitation-27791083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27791083 |
| http://purl.uniprot.org/uniprot/#_P47075-mappedCitation-27791083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27791083 |
| http://purl.uniprot.org/uniprot/#_Q02725-mappedCitation-27791083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27791083 |
| http://purl.uniprot.org/uniprot/#_Q04373-mappedCitation-27791083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27791083 |
| http://purl.uniprot.org/uniprot/#_P19262-mappedCitation-27791083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27791083 |
| http://purl.uniprot.org/uniprot/#_P32867-mappedCitation-27791083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27791083 |