| http://purl.uniprot.org/citations/27791279 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27791279 | http://www.w3.org/2000/01/rdf-schema#comment | "The epithelial-mesenchymal transition (EMT) is involved in many different types of cellular behavior, including liver fibrosis. In this report, we studied a novel function of RAR-related orphan receptor gamma (ROR-γ) in hepatocyte EMT during liver fibrosis. To induce EMT in vitro, primary hepatocytes and FL83B cells were treated with TGF-β1. Expression of ROR-γ was analyzed by Western blot in the fibrotic mouse livers and human livers with cirrhosis. To verify the role of ROR-γ in hepatocyte EMT, we silenced ROR-γ in FL83B cells using a lentiviral short hairpin RNA (shRNA) vector. The therapeutic effect of ROR-γ silencing was investigated in a mouse model of TAA-induced fibrosis by hydrodynamic injection of plasmids. ROR-γ expression was elevated in hepatocyte cells treated with TGF-β1, and ROR-γ protein levels were elevated in the fibrotic mouse livers and human livers with cirrhosis. Knockdown of ROR-γ resulted in the attenuation of TGF-β1-induced EMT in hepatocytes. Strikingly, ROR-γ bound to ROR-specific DNA response elements (ROREs) in the promoter region of TGF-β type I receptor (Tgfbr1) and Smad2, resulting in the downregulation of Tgfbr1 and Smad2 after silencing of ROR-γ. Therapeutic delivery of shRNA against ROR-γ attenuated hepatocyte EMT and ameliorated liver fibrosis in a mouse model of TAA-induced liver fibrosis. Overall, our results suggest that ROR-γ regulates TGF-β-induced EMT in hepatocytes during liver fibrosis. We suggest that ROR-γ may become a potential therapeutic target in treating liver fibrosis. J. Cell. Biochem. 118: 2026-2036, 2017. © 2016 The Authors. Journal of Cellular Biochemistry Published by Wiley Periodicals Inc."xsd:string |
| http://purl.uniprot.org/citations/27791279 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.25776"xsd:string |
| http://purl.uniprot.org/citations/27791279 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/27791279 | http://purl.uniprot.org/core/author | "Kim S.M."xsd:string |
| http://purl.uniprot.org/citations/27791279 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/27791279 | http://purl.uniprot.org/core/author | "Hong S.W."xsd:string |
| http://purl.uniprot.org/citations/27791279 | http://purl.uniprot.org/core/author | "Choi J.E."xsd:string |
| http://purl.uniprot.org/citations/27791279 | http://purl.uniprot.org/core/author | "Yoon S.K."xsd:string |
| http://purl.uniprot.org/citations/27791279 | http://purl.uniprot.org/core/author | "Li T.Z."xsd:string |
| http://purl.uniprot.org/citations/27791279 | http://purl.uniprot.org/core/author | "Hur W."xsd:string |
| http://purl.uniprot.org/citations/27791279 | http://purl.uniprot.org/core/author | "Lee E.B."xsd:string |
| http://purl.uniprot.org/citations/27791279 | http://purl.uniprot.org/core/author | "Sung P.S."xsd:string |
| http://purl.uniprot.org/citations/27791279 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27791279 | http://purl.uniprot.org/core/name | "J Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/27791279 | http://purl.uniprot.org/core/pages | "2026-2036"xsd:string |
| http://purl.uniprot.org/citations/27791279 | http://purl.uniprot.org/core/title | "RAR-Related Orphan Receptor Gamma (ROR-gamma) Mediates Epithelial-Mesenchymal Transition Of Hepatocytes During Hepatic Fibrosis."xsd:string |
| http://purl.uniprot.org/citations/27791279 | http://purl.uniprot.org/core/volume | "118"xsd:string |
| http://purl.uniprot.org/citations/27791279 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27791279 |
| http://purl.uniprot.org/citations/27791279 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27791279 |
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| http://purl.uniprot.org/uniprot/#_A0A078BCJ0-mappedCitation-27791279 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27791279 |
| http://purl.uniprot.org/uniprot/#_A0A078BCH8-mappedCitation-27791279 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27791279 |