| http://purl.uniprot.org/citations/27793841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27793841 | http://www.w3.org/2000/01/rdf-schema#comment | "The RB1/E2F1 signaling pathway is frequently deregulated in colorectal cancer and has been suggested to intersect with Wnt/β-catenin and PI3K/Akt pathways, but molecular evidence for this link is lacking. In this study, we demonstrate that phospholipase D1 (PLD1), a transcriptional target of β-catenin/TCF4, orchestrates functional interactions between these pathways during intestinal tumor development. Overexpression of PLD1 in intestinal epithelial cells protected cells from apoptosis induced by PLD1 ablation in the Apcmin/+ mouse model of intestinal tumorigenesis. Mechanistic investigations revealed that genetic and pharmacologic targeting of PLD1 promote the E2F1-dependent apoptotic program via both miR-192/4465-mediated downregulation of RB1 and inhibition of Akt-TopBP1 pathways. Moreover, the miRNA-RB1 axis and Akt pathway also contributed to the PLD1-mediated self-renewal capacity of colon cancer-initiating cells. Finally, PLD1-driven E2F1 target gene expression positively correlated with tumor stage in patients with colorectal cancer. Overall, our findings suggest that PLD1 mediates cross-talk between multiple major signaling pathways to promote the survival and malignancy of colon cancer cells and may therefore represent an ideal signaling node for therapeutic targeting. Cancer Res; 77(1); 142-52. ©2016 AACR."xsd:string |
| http://purl.uniprot.org/citations/27793841 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-15-3032"xsd:string |
| http://purl.uniprot.org/citations/27793841 | http://purl.uniprot.org/core/author | "Lee S.W."xsd:string |
| http://purl.uniprot.org/citations/27793841 | http://purl.uniprot.org/core/author | "Choi K.Y."xsd:string |
| http://purl.uniprot.org/citations/27793841 | http://purl.uniprot.org/core/author | "Choi Y.S."xsd:string |
| http://purl.uniprot.org/citations/27793841 | http://purl.uniprot.org/core/author | "Lee B.H."xsd:string |
| http://purl.uniprot.org/citations/27793841 | http://purl.uniprot.org/core/author | "Suh Y.A."xsd:string |
| http://purl.uniprot.org/citations/27793841 | http://purl.uniprot.org/core/author | "Hwang W.C."xsd:string |
| http://purl.uniprot.org/citations/27793841 | http://purl.uniprot.org/core/author | "Kang D.W."xsd:string |
| http://purl.uniprot.org/citations/27793841 | http://purl.uniprot.org/core/author | "Min D.S."xsd:string |
| http://purl.uniprot.org/citations/27793841 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27793841 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/27793841 | http://purl.uniprot.org/core/pages | "142-152"xsd:string |
| http://purl.uniprot.org/citations/27793841 | http://purl.uniprot.org/core/title | "Phospholipase D1 Acts through Akt/TopBP1 and RB1 to Regulate the E2F1-Dependent Apoptotic Program in Cancer Cells."xsd:string |
| http://purl.uniprot.org/citations/27793841 | http://purl.uniprot.org/core/volume | "77"xsd:string |
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