| http://purl.uniprot.org/citations/27795415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27795415 | http://www.w3.org/2000/01/rdf-schema#comment | "Gammaherpesviruses are ubiquitous pathogens that establish lifelong infection in >95% of adults worldwide and are associated with a variety of malignancies. Coevolution of gammaherpesviruses with their hosts has resulted in an intricate relationship between the virus and the host immune system, and perturbation of the virus-host balance results in pathology. Interferon regulatory factor 1 (IRF-1) is a tumor suppressor that is also involved in the regulation of innate and adaptive immune responses. Here, we show that type I interferon (IFN) and IRF-1 cooperate to control acute gammaherpesvirus infection. Specifically, we demonstrate that a combination of IRF-1 and type I IFN signaling ensures host survival during acute gammaherpesvirus infection and supports IFN gamma-mediated suppression of viral replication. Thus, our studies reveal an intriguing cross talk between IRF-1 and type I and II IFNs in the induction of the antiviral state during acute gammaherpesvirus infection.ImportanceGammaherpesviruses establish chronic infection in a majority of adults, and this long-term infection is associated with virus-driven development of a range of malignancies. In contrast, a brief period of active gammaherpesvirus replication during acute infection of a naive host is subclinical in most individuals. Here, we discovered that a combination of type I interferon (IFN) signaling and interferon regulatory factor 1 (IRF-1) expression is required to ensure survival of a gammaherpesvirus-infected host past the first 8 days of infection. Specifically, both type I IFN receptor and IRF-1 expression potentiated antiviral effects of type II IFN to restrict gammaherpesvirus replication in vivo, in the lungs, and in vitro, in primary macrophage cultures."xsd:string |
| http://purl.uniprot.org/citations/27795415 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.01444-16"xsd:string |
| http://purl.uniprot.org/citations/27795415 | http://purl.uniprot.org/core/author | "Anderson S."xsd:string |
| http://purl.uniprot.org/citations/27795415 | http://purl.uniprot.org/core/author | "Tarakanova V.L."xsd:string |
| http://purl.uniprot.org/citations/27795415 | http://purl.uniprot.org/core/author | "Mboko W.P."xsd:string |
| http://purl.uniprot.org/citations/27795415 | http://purl.uniprot.org/core/author | "Lange P.T."xsd:string |
| http://purl.uniprot.org/citations/27795415 | http://purl.uniprot.org/core/author | "Ledwith M.P."xsd:string |
| http://purl.uniprot.org/citations/27795415 | http://purl.uniprot.org/core/author | "Rekow M.M."xsd:string |
| http://purl.uniprot.org/citations/27795415 | http://purl.uniprot.org/core/author | "Schmitz K.E."xsd:string |
| http://purl.uniprot.org/citations/27795415 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27795415 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/27795415 | http://purl.uniprot.org/core/pages | "e01444-16"xsd:string |
| http://purl.uniprot.org/citations/27795415 | http://purl.uniprot.org/core/title | "Interferon Regulatory Factor 1 and Type I Interferon Cooperate To Control Acute Gammaherpesvirus Infection."xsd:string |
| http://purl.uniprot.org/citations/27795415 | http://purl.uniprot.org/core/volume | "91"xsd:string |
| http://purl.uniprot.org/citations/27795415 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27795415 |
| http://purl.uniprot.org/citations/27795415 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27795415 |
| http://purl.uniprot.org/uniprot/#_P15314-mappedCitation-27795415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27795415 |
| http://purl.uniprot.org/uniprot/#_Q0VE17-mappedCitation-27795415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27795415 |
| http://purl.uniprot.org/uniprot/#_A0A338P6T9-mappedCitation-27795415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27795415 |
| http://purl.uniprot.org/uniprot/#_A0A338P6X7-mappedCitation-27795415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27795415 |
| http://purl.uniprot.org/uniprot/#_A0A384DVB8-mappedCitation-27795415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27795415 |
| http://purl.uniprot.org/uniprot/#_A8Y5B9-mappedCitation-27795415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27795415 |
| http://purl.uniprot.org/uniprot/#_E9PWM1-mappedCitation-27795415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27795415 |
| http://purl.uniprot.org/uniprot/#_D6RH71-mappedCitation-27795415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27795415 |