| http://purl.uniprot.org/citations/27799548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27799548 | http://www.w3.org/2000/01/rdf-schema#comment | "The protein encoded by the autoimmune-associated protein tyrosine phosphatase nonreceptor type 22 gene, PTPN22, has wide-ranging effects in immune cells including suppression of T-cell receptor signaling and promoting efficient production of type I interferons (IFN-I) by myeloid cells. Here we show that mice deficient in PTPN22 resist chronic viral infection with lymphocytic choriomeningitis virus clone 13 (LCMV cl13). The numbers and function of viral-specific CD4 T lymphocytes is greatly enhanced, whereas expression of the IFNβ-induced IL-2 repressor, cAMP-responsive element modulator (CREM) is reduced. Reduction of CREM expression in wild-type CD4 T lymphocytes prevents the loss of IL-2 production by CD4 T lymphocytes during infection with LCMV cl13. These findings implicate the IFNβ/CREM/IL-2 axis in regulating T-lymphocyte function during chronic viral infection."xsd:string |
| http://purl.uniprot.org/citations/27799548 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1603738113"xsd:string |
| http://purl.uniprot.org/citations/27799548 | http://purl.uniprot.org/core/author | "Sherman L.A."xsd:string |
| http://purl.uniprot.org/citations/27799548 | http://purl.uniprot.org/core/author | "Teijaro J.R."xsd:string |
| http://purl.uniprot.org/citations/27799548 | http://purl.uniprot.org/core/author | "Marquardt K."xsd:string |
| http://purl.uniprot.org/citations/27799548 | http://purl.uniprot.org/core/author | "Maine C.J."xsd:string |
| http://purl.uniprot.org/citations/27799548 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27799548 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/27799548 | http://purl.uniprot.org/core/pages | "E7231-E7239"xsd:string |
| http://purl.uniprot.org/citations/27799548 | http://purl.uniprot.org/core/title | "PTPN22 contributes to exhaustion of T lymphocytes during chronic viral infection."xsd:string |
| http://purl.uniprot.org/citations/27799548 | http://purl.uniprot.org/core/volume | "113"xsd:string |
| http://purl.uniprot.org/citations/27799548 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27799548 |
| http://purl.uniprot.org/citations/27799548 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27799548 |
| http://purl.uniprot.org/uniprot/#_E9QAS3-mappedCitation-27799548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27799548 |
| http://purl.uniprot.org/uniprot/#_P29352-mappedCitation-27799548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27799548 |
| http://purl.uniprot.org/uniprot/#_Q3TEL9-mappedCitation-27799548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27799548 |
| http://purl.uniprot.org/uniprot/P29352 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27799548 |
| http://purl.uniprot.org/uniprot/E9QAS3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27799548 |
| http://purl.uniprot.org/uniprot/Q3TEL9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27799548 |