| http://purl.uniprot.org/citations/27802137 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27802137 | http://www.w3.org/2000/01/rdf-schema#comment | "One of the key issues in studying transcriptional regulation during development is how to employ genome-wide assays that reveals sites of open chromatin and transcription factor binding to efficiently identify biologically relevant genes and enhancers. Analysis of Drosophila CNS midline cell development provides a useful system for studying transcriptional regulation at the genomic level due to a large, well-characterized set of midline-expressed genes and in vivo validated enhancers. In this study, FAIRE-seq on FACS-purified midline cells was performed and the midline FAIRE data were compared with whole-embryo FAIRE data. We find that regions of the genome with a strong midline FAIRE peak and weak whole-embryo FAIRE peak overlap with known midline enhancers and provide a useful predictive tool for enhancer identification. In a complementary analysis, we compared a large dataset of fragments that drive midline expression in vivo with the FAIRE data. Midline enhancer fragments with a midline FAIRE peak tend to be near midline-expressed genes, whereas midline enhancers without a midline FAIRE peak were often distant from midline-expressed genes and unlikely to drive midline transcription in vivo."xsd:string |
| http://purl.uniprot.org/citations/27802137 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.136895"xsd:string |
| http://purl.uniprot.org/citations/27802137 | http://purl.uniprot.org/core/author | "Crews S.T."xsd:string |
| http://purl.uniprot.org/citations/27802137 | http://purl.uniprot.org/core/author | "Lieb J.D."xsd:string |
| http://purl.uniprot.org/citations/27802137 | http://purl.uniprot.org/core/author | "McKay D.J."xsd:string |
| http://purl.uniprot.org/citations/27802137 | http://purl.uniprot.org/core/author | "Pearson J.C."xsd:string |
| http://purl.uniprot.org/citations/27802137 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27802137 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/27802137 | http://purl.uniprot.org/core/pages | "3723-3732"xsd:string |
| http://purl.uniprot.org/citations/27802137 | http://purl.uniprot.org/core/title | "Chromatin profiling of Drosophila CNS subpopulations identifies active transcriptional enhancers."xsd:string |
| http://purl.uniprot.org/citations/27802137 | http://purl.uniprot.org/core/volume | "143"xsd:string |
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