| http://purl.uniprot.org/citations/27807029 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27807029 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatitis delta virus (HDV) is a satellite virus of hepatitis B virus (HBV). HDV genome encodes two forms of hepatitis delta antigen (HDAg), small HDAg (HDAg-S), which is required for viral replication, and large HDAg (HDAg-L), which is essential for viral assembly. HDAg-L is identical to HDAg-S except that it bears a 19-amino acid extension at the C terminus. Both HDAgs contain a nuclear localization signal (NLS), but only HDAg-L contains a CRM1-independent nuclear export signal at its C terminus. The nuclear export activity of HDAg-L is important for HDV particle formation. However, the mechanisms of HDAg-L-mediated nuclear export of HDV ribonucleoprotein are not clear. In this study, the host cellular RNA export complex TAP-Aly was found to form a complex with HDAg-L, but not with an export-defective HDAg-L mutant, in which Pro205 was replaced by Ala. HDAg-L was found to colocalize with TAP and Aly in the nucleus. The C-terminal domain of HDAg-L was shown to directly interact with the N terminus of TAP, whereas an HDAg-L mutant lacking the NLS failed to interact with full-length TAP. In addition, small hairpin RNA-mediated down-regulation of TAP or Aly reduced nuclear export of HDAg-L and assembly of HDV virions. Furthermore, a peptide, TAT-HDAg-L(198-210), containing the 10-amino acid TAT peptide and HDAg-L(198-210), inhibited the interaction between HDAg-L and TAP and blocked HDV virion assembly and secretion. These data demonstrate that formation and release of HDV particles are mediated by TAP and Aly."xsd:string |
| http://purl.uniprot.org/citations/27807029 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m116.754853"xsd:string |
| http://purl.uniprot.org/citations/27807029 | http://purl.uniprot.org/core/author | "Huang C."xsd:string |
| http://purl.uniprot.org/citations/27807029 | http://purl.uniprot.org/core/author | "Lee Y.C."xsd:string |
| http://purl.uniprot.org/citations/27807029 | http://purl.uniprot.org/core/author | "Chang M.F."xsd:string |
| http://purl.uniprot.org/citations/27807029 | http://purl.uniprot.org/core/author | "Huang H.C."xsd:string |
| http://purl.uniprot.org/citations/27807029 | http://purl.uniprot.org/core/author | "Lee C.P."xsd:string |
| http://purl.uniprot.org/citations/27807029 | http://purl.uniprot.org/core/author | "Lai Y.H."xsd:string |
| http://purl.uniprot.org/citations/27807029 | http://purl.uniprot.org/core/author | "Liu H.K."xsd:string |
| http://purl.uniprot.org/citations/27807029 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27807029 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/27807029 | http://purl.uniprot.org/core/pages | "26226-26238"xsd:string |
| http://purl.uniprot.org/citations/27807029 | http://purl.uniprot.org/core/title | "Cellular Nuclear Export Factors TAP and Aly Are Required for HDAg-L-mediated Assembly of Hepatitis Delta Virus."xsd:string |
| http://purl.uniprot.org/citations/27807029 | http://purl.uniprot.org/core/volume | "291"xsd:string |
| http://purl.uniprot.org/citations/27807029 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27807029 |
| http://purl.uniprot.org/citations/27807029 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27807029 |
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