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| http://purl.uniprot.org/citations/27807998 | http://www.w3.org/2000/01/rdf-schema#comment | "GPR142 is a G-protein-coupled receptor (GPCR), whose most potent and efficacious ligand has been reported as being the natural amino acid l-tryptophan. GPR142 is highly expressed in pancreatic β-cells and immune cells, suggesting the receptor may play a role in the pathogenesis and development of diabetes or inflammatory diseases. In a previous report, we developed GPR142 agonists as insulin secretagogues. In this report, we show the discovery of a selective, potent small-molecule GPR142 antagonist, CLP-3094, and its pharmacological characteristics. These data support targeting this receptor for the treatment of chronic inflammatory diseases."xsd:string |
| http://purl.uniprot.org/citations/27807998 | http://purl.org/dc/terms/identifier | "doi:10.1080/10799893.2016.1247861"xsd:string |
| http://purl.uniprot.org/citations/27807998 | http://purl.uniprot.org/core/author | "Maeda H."xsd:string |
| http://purl.uniprot.org/citations/27807998 | http://purl.uniprot.org/core/author | "Nagasaki M."xsd:string |
| http://purl.uniprot.org/citations/27807998 | http://purl.uniprot.org/core/author | "Kuwabara H."xsd:string |
| http://purl.uniprot.org/citations/27807998 | http://purl.uniprot.org/core/author | "Nara F."xsd:string |
| http://purl.uniprot.org/citations/27807998 | http://purl.uniprot.org/core/author | "Reagan J.D."xsd:string |
| http://purl.uniprot.org/citations/27807998 | http://purl.uniprot.org/core/author | "Xiong Y.M."xsd:string |
| http://purl.uniprot.org/citations/27807998 | http://purl.uniprot.org/core/author | "Murakoshi M."xsd:string |
| http://purl.uniprot.org/citations/27807998 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27807998 | http://purl.uniprot.org/core/name | "J Recept Signal Transduct Res"xsd:string |
| http://purl.uniprot.org/citations/27807998 | http://purl.uniprot.org/core/pages | "290-296"xsd:string |
| http://purl.uniprot.org/citations/27807998 | http://purl.uniprot.org/core/title | "Discovery and pharmacological effects of a novel GPR142 antagonist."xsd:string |
| http://purl.uniprot.org/citations/27807998 | http://purl.uniprot.org/core/volume | "37"xsd:string |
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