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| http://purl.uniprot.org/citations/27808506 | http://www.w3.org/2000/01/rdf-schema#comment | "Glutamate dehydrogenase (GDH) catalyzes the oxidative deamination of l-glutamate and in animals is highly regulated. GDH in hyperinsulinism/hyperammonemia syndrome patients lacks GTP inhibition, resulting in hypersecretion of insulin upon protein consumption. This suggests insulin secretion could be stimulated with GDH activators. A high-throughput screen yielded one potent activator, N1-[4-(2-aminopyrimidin-4-yl)phenyl]-3-(trifluoromethyl)benzene-1-sulfonamide (75-E10). 75-E10 is ∼1000-fold more efficacious than the synthetic activator, BCH, and is at least as effective as ADP. 75-E10 compound is highly effective at alleviating GTP inhibition and may be binding to the ADP site. Unlike ADP, 75-E10 is activated over a broad range of conditions."xsd:string |
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| http://purl.uniprot.org/citations/27808506 | http://purl.uniprot.org/core/author | "Smith T.J."xsd:string |
| http://purl.uniprot.org/citations/27808506 | http://purl.uniprot.org/core/author | "Smith H.Q."xsd:string |
| http://purl.uniprot.org/citations/27808506 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27808506 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
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| http://purl.uniprot.org/citations/27808506 | http://purl.uniprot.org/core/title | "Identification of a Novel Activator of Mammalian Glutamate Dehydrogenase."xsd:string |
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