| http://purl.uniprot.org/citations/27810071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27810071 | http://www.w3.org/2000/01/rdf-schema#comment | "A cohort comprising 156 patients with B-cell neoplasms harboring an MYC rearrangement was analyzed with respect to phenotypic presentation, molecular markers (TP53, MYC and ID3) and additional cytogenetic abnormalities (concomitantly occurring BCL2, BCL6 and/or CCND1 rearrangements; double, triple or quadruple hit lymphomas = multiple hit lymphomas). MYC translocations occurred as single hit (only MYC rearranged, 63%) or multiple hit lymphoma (37%) and presented as acute leukemia (AL) (14%), Burkitt lymphoma (30%), chronic lymphocytic leukemia (CLL) (21%) or other mature B-cell neoplasms (35%). Multiple hit lymphomas more frequently showed a complex karyotype compared to single hit lymphomas (62% vs. 28%, p < 0.001). Single hit Burkitt lymphomas presented with specific characteristics, by translocation of MYC to an immunoglobulin locus, predominantly a non-complex karyotype (23% vs. 67%, p = 0.012) and a significantly higher ID3 and TP53 mutation frequency (ID3mut: 49% vs. 0%, p = 0.002; TP53mut: 69% vs. 33%, p = 0.045). Additionally, MYC rearranged CLL presented as outstanding group by often showing a non-complex karyotype (85%), absence of ID3 mutations, a high frequency of SF3B1 mutations, and a frequent involvement of non-immunoglobulin loci as MYC-partner genes (61%). Consequently, genetic characteristics distinguish different subgroups of MYC rearranged B-cell neoplasms and therefore may contribute to a new classification system."xsd:string |
| http://purl.uniprot.org/citations/27810071 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cancergen.2016.08.007"xsd:string |
| http://purl.uniprot.org/citations/27810071 | http://purl.uniprot.org/core/author | "Stengel A."xsd:string |
| http://purl.uniprot.org/citations/27810071 | http://purl.uniprot.org/core/author | "Haferlach T."xsd:string |
| http://purl.uniprot.org/citations/27810071 | http://purl.uniprot.org/core/author | "Kern W."xsd:string |
| http://purl.uniprot.org/citations/27810071 | http://purl.uniprot.org/core/author | "Haferlach C."xsd:string |
| http://purl.uniprot.org/citations/27810071 | http://purl.uniprot.org/core/author | "Haberl S."xsd:string |
| http://purl.uniprot.org/citations/27810071 | http://purl.uniprot.org/core/author | "Jeromin S."xsd:string |
| http://purl.uniprot.org/citations/27810071 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27810071 | http://purl.uniprot.org/core/name | "Cancer Genet"xsd:string |
| http://purl.uniprot.org/citations/27810071 | http://purl.uniprot.org/core/pages | "431-439"xsd:string |
| http://purl.uniprot.org/citations/27810071 | http://purl.uniprot.org/core/title | "MYC rearranged B-cell neoplasms: Impact of genetics on classification."xsd:string |
| http://purl.uniprot.org/citations/27810071 | http://purl.uniprot.org/core/volume | "209"xsd:string |
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