| http://purl.uniprot.org/citations/27810925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27810925 | http://www.w3.org/2000/01/rdf-schema#comment | "Toll-like receptor 7 (TLR7) plays an essential role in development of systemic lupus erythematosus by co-stimulating B cells reactive to the endogenous TLR7 ligand Sm/ribonucleoprotein (RNP), a crucial lupus self-antigen. However, how the TLR7-mediated autoimmune response is regulated is not yet known. In this study, we demonstrate that CD72, an inhibitory B cell co-receptor known to prevent development of lupus, recognizes Sm/RNP at the extracellular C-type lectin-like domain (CTLD) and specifically inhibits B cell response to Sm/RNP. Moreover, the CTLD of CD72c, a lupus-susceptible allele, binds to Sm/RNP less strongly than that of lupus-resistant CD72a Reduced binding of CD72c is supported by x-ray crystallographic analysis that reveals a considerable alteration in charge at the putative ligand-binding site. Thus, CD72 appears to specifically inhibit B cell response to the endogenous TLR7 ligand Sm/RNP through CTLD-mediated recognition of Sm/RNP, thereby preventing production of anti-Sm/RNP antibody crucial for development of lupus."xsd:string |
| http://purl.uniprot.org/citations/27810925 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20160560"xsd:string |
| http://purl.uniprot.org/citations/27810925 | http://purl.uniprot.org/core/author | "Adachi T."xsd:string |
| http://purl.uniprot.org/citations/27810925 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/27810925 | http://purl.uniprot.org/core/author | "Furukawa K."xsd:string |
| http://purl.uniprot.org/citations/27810925 | http://purl.uniprot.org/core/author | "Ito N."xsd:string |
| http://purl.uniprot.org/citations/27810925 | http://purl.uniprot.org/core/author | "Aslam M."xsd:string |
| http://purl.uniprot.org/citations/27810925 | http://purl.uniprot.org/core/author | "Shinagawa K."xsd:string |
| http://purl.uniprot.org/citations/27810925 | http://purl.uniprot.org/core/author | "Tsubata T."xsd:string |
| http://purl.uniprot.org/citations/27810925 | http://purl.uniprot.org/core/author | "Numoto N."xsd:string |
| http://purl.uniprot.org/citations/27810925 | http://purl.uniprot.org/core/author | "Akatsu C."xsd:string |
| http://purl.uniprot.org/citations/27810925 | http://purl.uniprot.org/core/author | "Phoon S."xsd:string |
| http://purl.uniprot.org/citations/27810925 | http://purl.uniprot.org/core/author | "Ucar A.K."xsd:string |
| http://purl.uniprot.org/citations/27810925 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27810925 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/27810925 | http://purl.uniprot.org/core/pages | "2691-2706"xsd:string |
| http://purl.uniprot.org/citations/27810925 | http://purl.uniprot.org/core/title | "CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP."xsd:string |
| http://purl.uniprot.org/citations/27810925 | http://purl.uniprot.org/core/volume | "213"xsd:string |
| http://purl.uniprot.org/citations/27810925 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27810925 |
| http://purl.uniprot.org/citations/27810925 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27810925 |
| http://purl.uniprot.org/uniprot/#_A2AHJ1-mappedCitation-27810925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27810925 |
| http://purl.uniprot.org/uniprot/#_A2AHJ2-mappedCitation-27810925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27810925 |
| http://purl.uniprot.org/uniprot/#_A2AIN5-mappedCitation-27810925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27810925 |
| http://purl.uniprot.org/uniprot/#_P58681-mappedCitation-27810925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27810925 |