| http://purl.uniprot.org/citations/2781509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2781509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2781509 | http://www.w3.org/2000/01/rdf-schema#comment | "Antithrombin Chicago is a functionally inactive antithrombin variant whose inheritance is associated with thrombotic disease. The variant antithrombin was isolated from plasma of the propositus by chromatography on heparin-Sepharose, followed by passage through thrombin-Sepharose to remove the normal antithrombin component that is present. A pool of fragments ("CNBr pool 4") containing the reactive site region was prepared from the reduced and S-carboxymethylated variant by cleavage with cyanogen bromide followed by reverse-phase HPLC. Sequential treatment of CNBr pool 4 with trypsin and V8 protease produced peptides whose molecular masses were then determined by fast atom bombardment mass spectrometry. The variant protein digests were characterised by a reduction of a peptide of mass 1086, corresponding to the normal antithrombin sequence Ala382-Arg393. However, they contained a peptide of mass 1748, which arises when Arg393 is replaced by His in the sequence Ala382-Arg399. It is concluded that the functional and clinical abnormalities of antithrombin Chicago are all probably caused by a single amino acid substitution, Arg393 to His."xsd:string |
| http://purl.uniprot.org/citations/2781509 | http://purl.org/dc/terms/identifier | "doi:10.1016/0049-3848(89)90127-8"xsd:string |
| http://purl.uniprot.org/citations/2781509 | http://purl.org/dc/terms/identifier | "doi:10.1016/0049-3848(89)90127-8"xsd:string |
| http://purl.uniprot.org/citations/2781509 | http://purl.uniprot.org/core/author | "Morris H.R."xsd:string |
| http://purl.uniprot.org/citations/2781509 | http://purl.uniprot.org/core/author | "Morris H.R."xsd:string |
| http://purl.uniprot.org/citations/2781509 | http://purl.uniprot.org/core/author | "Panico M."xsd:string |
| http://purl.uniprot.org/citations/2781509 | http://purl.uniprot.org/core/author | "Panico M."xsd:string |
| http://purl.uniprot.org/citations/2781509 | http://purl.uniprot.org/core/author | "Bauer K."xsd:string |
| http://purl.uniprot.org/citations/2781509 | http://purl.uniprot.org/core/author | "Bauer K."xsd:string |
| http://purl.uniprot.org/citations/2781509 | http://purl.uniprot.org/core/author | "Rosenberg R.D."xsd:string |
| http://purl.uniprot.org/citations/2781509 | http://purl.uniprot.org/core/author | "Rosenberg R.D."xsd:string |
| http://purl.uniprot.org/citations/2781509 | http://purl.uniprot.org/core/author | "Erdjument H."xsd:string |
| http://purl.uniprot.org/citations/2781509 | http://purl.uniprot.org/core/author | "Erdjument H."xsd:string |
| http://purl.uniprot.org/citations/2781509 | http://purl.uniprot.org/core/author | "Lane D.A."xsd:string |
| http://purl.uniprot.org/citations/2781509 | http://purl.uniprot.org/core/author | "Lane D.A."xsd:string |
| http://purl.uniprot.org/citations/2781509 | http://purl.uniprot.org/core/author | "di Marzo V."xsd:string |
| http://purl.uniprot.org/citations/2781509 | http://purl.uniprot.org/core/author | "di Marzo V."xsd:string |
| http://purl.uniprot.org/citations/2781509 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2781509 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2781509 | http://purl.uniprot.org/core/name | "Thromb. Res."xsd:string |
| http://purl.uniprot.org/citations/2781509 | http://purl.uniprot.org/core/name | "Thromb. Res."xsd:string |
| http://purl.uniprot.org/citations/2781509 | http://purl.uniprot.org/core/pages | "613-619"xsd:string |
| http://purl.uniprot.org/citations/2781509 | http://purl.uniprot.org/core/pages | "613-619"xsd:string |