| http://purl.uniprot.org/citations/27815257 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27815257 | http://www.w3.org/2000/01/rdf-schema#comment | "Myofibroblast differentiation is a key process in the pathogenesis of fibrotic diseases. Transforming growth factor-β1 (TGF-β1) is a powerful inducer of myofibroblast differentiation and is implicated in pathogenesis of tissue fibrosis. This study was undertaken to determine the role of mitochondrial deacetylase SIRT3 in TGF-β1-induced myofibroblast differentiation in vitro and lung fibrosis in vivo. Treatment of human lung fibroblasts with TGF-β1 resulted in increased expression of fibrosis markers, smooth muscle α-actin (α-SMA), collagen-1, and fibronectin. TGF-β1 treatment also caused depletion of endogenous SIRT3, which paralleled with increased production of reactive oxygen species (ROS), DNA damage, and subsequent reduction in levels of 8-oxoguanine DNA glycosylase (OGG1), an enzyme that hydrolyzes oxidized guanine (8-oxo-dG) and thus protects DNA from oxidative damage. Overexpression of SIRT3 by adenovirus-mediated transduction reversed the effects of TGF-β1 on ROS production and mitochondrial DNA damage and inhibited TGF-β1-induced myofibroblast differentiation. To determine the antifibrotic role of SIRT3 in vivo, we used the bleomycin-induced mouse model of pulmonary fibrosis. Compared with wild-type controls, Sirt3-knockout mice showed exacerbated fibrosis after intratracheal instillation of bleomycin. Increased lung fibrosis was associated with decreased levels of OGG1 and concomitant accumulation of 8-oxo-dG and increased mitochondrial DNA damage. In contrast, the transgenic mice with whole body Sirt3 overexpression were protected from bleomycin-induced mtDNA damage and development of lung fibrosis. These data demonstrate a critical role of SIRT3 in the control of myofibroblast differentiation and lung fibrosis."xsd:string |
| http://purl.uniprot.org/citations/27815257 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajplung.00188.2016"xsd:string |
| http://purl.uniprot.org/citations/27815257 | http://purl.uniprot.org/core/author | "Verdin E."xsd:string |
| http://purl.uniprot.org/citations/27815257 | http://purl.uniprot.org/core/author | "Bindu S."xsd:string |
| http://purl.uniprot.org/citations/27815257 | http://purl.uniprot.org/core/author | "Gupta M.P."xsd:string |
| http://purl.uniprot.org/citations/27815257 | http://purl.uniprot.org/core/author | "Pillai V.B."xsd:string |
| http://purl.uniprot.org/citations/27815257 | http://purl.uniprot.org/core/author | "Samant S."xsd:string |
| http://purl.uniprot.org/citations/27815257 | http://purl.uniprot.org/core/author | "Kanwal A."xsd:string |
| http://purl.uniprot.org/citations/27815257 | http://purl.uniprot.org/core/author | "Dulin N."xsd:string |
| http://purl.uniprot.org/citations/27815257 | http://purl.uniprot.org/core/author | "Mutlu G.M."xsd:string |
| http://purl.uniprot.org/citations/27815257 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27815257 | http://purl.uniprot.org/core/name | "Am J Physiol Lung Cell Mol Physiol"xsd:string |
| http://purl.uniprot.org/citations/27815257 | http://purl.uniprot.org/core/pages | "L68-L78"xsd:string |
| http://purl.uniprot.org/citations/27815257 | http://purl.uniprot.org/core/title | "SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage."xsd:string |
| http://purl.uniprot.org/citations/27815257 | http://purl.uniprot.org/core/volume | "312"xsd:string |
| http://purl.uniprot.org/citations/27815257 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27815257 |
| http://purl.uniprot.org/citations/27815257 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27815257 |
| http://purl.uniprot.org/uniprot/#_D3YVQ5-mappedCitation-27815257 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27815257 |
| http://purl.uniprot.org/uniprot/#_D3YWD6-mappedCitation-27815257 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27815257 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRF7-mappedCitation-27815257 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27815257 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRY5-mappedCitation-27815257 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27815257 |
| http://purl.uniprot.org/uniprot/#_B7ZA60-mappedCitation-27815257 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27815257 |
| http://purl.uniprot.org/uniprot/#_B7Z777-mappedCitation-27815257 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27815257 |
| http://purl.uniprot.org/uniprot/#_B7Z7G4-mappedCitation-27815257 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27815257 |