| http://purl.uniprot.org/citations/27816669 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27816669 | http://www.w3.org/2000/01/rdf-schema#comment | "Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the development of autoantibodies that drive disease pathogenesis. Genetic studies have associated nonsynonymous variants in the BANK1 B cell scaffolding gene with susceptibility to SLE and autoantibodies in lupus. To determine how the BANK1 SLE-risk variants contribute to the dysregulated B cell program in lupus, we performed genotype/phenotype studies in human B cells. Targeted phospho-proteomics were used to evaluate BCR/CD40 signaling in human B cell lines engineered to express the BANK1 risk or non-risk variant proteins. We found that phosphorylation of proximal BCR signaling molecules was reduced in B cells expressing the BANK1 risk protein compared to the non-risk protein. Similar to these findings, we observed decreased B cell signaling in primary B cells from genotyped healthy control subjects carrying the BANK1 risk haplotype, including blunted BCR- and CD40-dependent AKT activation. Consistent with decreased AKT activation, we found that BANK1 risk B cells expressed increased basal levels of FOXO1 protein and increased expression of FOXO1 target genes upon stimulation compared to non-risk B cells. Healthy subjects carrying the BANK1 risk haplotype were also characterized by an expansion of memory B cells. Taken together, our results suggest that the SLE susceptibility variants in the BANK1 gene may contribute to lupus by altering B cell signaling, increasing FOXO1 levels, and enhancing memory B cell development."xsd:string |
| http://purl.uniprot.org/citations/27816669 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.clim.2016.10.018"xsd:string |
| http://purl.uniprot.org/citations/27816669 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/27816669 | http://purl.uniprot.org/core/author | "Funk A."xsd:string |
| http://purl.uniprot.org/citations/27816669 | http://purl.uniprot.org/core/author | "James R."xsd:string |
| http://purl.uniprot.org/citations/27816669 | http://purl.uniprot.org/core/author | "Wei S."xsd:string |
| http://purl.uniprot.org/citations/27816669 | http://purl.uniprot.org/core/author | "Habib T."xsd:string |
| http://purl.uniprot.org/citations/27816669 | http://purl.uniprot.org/core/author | "Buckner J.H."xsd:string |
| http://purl.uniprot.org/citations/27816669 | http://purl.uniprot.org/core/author | "Cerosaletti K."xsd:string |
| http://purl.uniprot.org/citations/27816669 | http://purl.uniprot.org/core/author | "Glukhova V."xsd:string |
| http://purl.uniprot.org/citations/27816669 | http://purl.uniprot.org/core/author | "Dam E.M."xsd:string |
| http://purl.uniprot.org/citations/27816669 | http://purl.uniprot.org/core/author | "Davis-Pickett M."xsd:string |
| http://purl.uniprot.org/citations/27816669 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27816669 | http://purl.uniprot.org/core/name | "Clin Immunol"xsd:string |
| http://purl.uniprot.org/citations/27816669 | http://purl.uniprot.org/core/pages | "171-180"xsd:string |
| http://purl.uniprot.org/citations/27816669 | http://purl.uniprot.org/core/title | "The BANK1 SLE-risk variants are associated with alterations in peripheral B cell signaling and development in humans."xsd:string |
| http://purl.uniprot.org/citations/27816669 | http://purl.uniprot.org/core/volume | "173"xsd:string |
| http://purl.uniprot.org/citations/27816669 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27816669 |
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