| http://purl.uniprot.org/citations/27821630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27821630 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondrial NADP+-dependent isocitrate dehydrogenase (IDH2) catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate, synthesizing NADPH, which is essential for mitochondrial redox balance. Ischemia-reperfusion (I/R) is one of most common causes of AKI. I/R disrupts the mitochondrial redox balance, resulting in oxidative damage to mitochondria and cells. Here, we investigated the role of IDH2 in I/R-induced AKI. I/R injury in mice led to the inactivation of IDH2 in kidney tubule cells. Idh2 gene deletion exacerbated the I/R-induced increase in plasma creatinine and BUN levels and the histologic evidence of tubule injury, and augmented the reduction of NADPH levels and the increase in oxidative stress observed in the kidney after I/R. Furthermore, Idh2 gene deletion exacerbated I/R-induced mitochondrial dysfunction and morphologic fragmentation, resulting in severe apoptosis in kidney tubule cells. In cultured mouse kidney proximal tubule cells, Idh2 gene downregulation enhanced the mitochondrial damage and apoptosis induced by treatment with hydrogen peroxide. This study demonstrates that Idh2 gene deletion exacerbates mitochondrial damage and tubular cell death via increased oxidative stress, suggesting that IDH2 is an important mitochondrial antioxidant enzyme that protects cells from I/R insult."xsd:string |
| http://purl.uniprot.org/citations/27821630 | http://purl.org/dc/terms/identifier | "doi:10.1681/asn.2016030349"xsd:string |
| http://purl.uniprot.org/citations/27821630 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/27821630 | http://purl.uniprot.org/core/author | "Park J.W."xsd:string |
| http://purl.uniprot.org/citations/27821630 | http://purl.uniprot.org/core/author | "Han S.J."xsd:string |
| http://purl.uniprot.org/citations/27821630 | http://purl.uniprot.org/core/author | "Kim J.I."xsd:string |
| http://purl.uniprot.org/citations/27821630 | http://purl.uniprot.org/core/author | "Park K.M."xsd:string |
| http://purl.uniprot.org/citations/27821630 | http://purl.uniprot.org/core/author | "Jang H.S."xsd:string |
| http://purl.uniprot.org/citations/27821630 | http://purl.uniprot.org/core/author | "Noh M.R."xsd:string |
| http://purl.uniprot.org/citations/27821630 | http://purl.uniprot.org/core/author | "Kong M.J."xsd:string |
| http://purl.uniprot.org/citations/27821630 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27821630 | http://purl.uniprot.org/core/name | "J Am Soc Nephrol"xsd:string |
| http://purl.uniprot.org/citations/27821630 | http://purl.uniprot.org/core/pages | "1200-1215"xsd:string |
| http://purl.uniprot.org/citations/27821630 | http://purl.uniprot.org/core/title | "Mitochondrial NADP+-Dependent Isocitrate Dehydrogenase Deficiency Exacerbates Mitochondrial and Cell Damage after Kidney Ischemia-Reperfusion Injury."xsd:string |
| http://purl.uniprot.org/citations/27821630 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/27821630 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27821630 |
| http://purl.uniprot.org/citations/27821630 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27821630 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP68-mappedCitation-27821630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27821630 |
| http://purl.uniprot.org/uniprot/#_P54071-mappedCitation-27821630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27821630 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RPR1-mappedCitation-27821630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27821630 |
| http://purl.uniprot.org/uniprot/#_D6RIL6-mappedCitation-27821630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27821630 |
| http://purl.uniprot.org/uniprot/P54071 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27821630 |
| http://purl.uniprot.org/uniprot/A0A0U1RPR1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27821630 |
| http://purl.uniprot.org/uniprot/D6RIL6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27821630 |