| http://purl.uniprot.org/citations/27821737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27821737 | http://www.w3.org/2000/01/rdf-schema#comment | "We have characterized a light-input pathway regulating Drosophila clock neuron excitability. The molecular clock drives rhythmic electrical excitability of clock neurons, and we show that the recently discovered light-input factor Quasimodo (Qsm) regulates this variation, presumably via an Na+, K+, Cl- cotransporter (NKCC) and the Shaw K+ channel (dKV3.1). Because of light-dependent degradation of the clock protein Timeless (Tim), constant illumination (LL) leads to a breakdown of molecular and behavioral rhythms. Both overexpression (OX) and knockdown (RNAi) of qsm, NKCC, or Shaw led to robust LL rhythmicity. Whole-cell recordings of the large ventral lateral neurons (l-LNv) showed that altering Qsm levels reduced the daily variation in neuronal activity: qsmOX led to a constitutive less active, night-like state, and qsmRNAi led to a more active, day-like state. Qsm also affected daily changes in K+ currents and the GABA reversal potential, suggesting a role in modifying membrane currents and GABA responses in a daily fashion, potentially modulating light arousal and input to the clock. When directly challenged with blue light, wild-type l-LNvs responded with increased firing at night and no net response during the day, whereas altering Qsm, NKKC, or Shaw levels abolished these day/night differences. Finally, coexpression of ShawOX and NKCCRNAi in a qsm mutant background restored LL-induced behavioral arrhythmicity and wild-type neuronal activity patterns, suggesting that the three genes operate in the same pathway. We propose that Qsm affects both daily and acute light effects in l-LNvs probably acting on Shaw and NKCC."xsd:string |
| http://purl.uniprot.org/citations/27821737 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1606547113"xsd:string |
| http://purl.uniprot.org/citations/27821737 | http://purl.uniprot.org/core/author | "Chen K.F."xsd:string |
| http://purl.uniprot.org/citations/27821737 | http://purl.uniprot.org/core/author | "Stanewsky R."xsd:string |
| http://purl.uniprot.org/citations/27821737 | http://purl.uniprot.org/core/author | "Hodge J.J."xsd:string |
| http://purl.uniprot.org/citations/27821737 | http://purl.uniprot.org/core/author | "Buhl E."xsd:string |
| http://purl.uniprot.org/citations/27821737 | http://purl.uniprot.org/core/author | "Ogueta M."xsd:string |
| http://purl.uniprot.org/citations/27821737 | http://purl.uniprot.org/core/author | "Bradlaugh A."xsd:string |
| http://purl.uniprot.org/citations/27821737 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27821737 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/27821737 | http://purl.uniprot.org/core/pages | "13486-13491"xsd:string |
| http://purl.uniprot.org/citations/27821737 | http://purl.uniprot.org/core/title | "Quasimodo mediates daily and acute light effects on Drosophila clock neuron excitability."xsd:string |
| http://purl.uniprot.org/citations/27821737 | http://purl.uniprot.org/core/volume | "113"xsd:string |
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