| http://purl.uniprot.org/citations/27824055 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27824055 | http://www.w3.org/2000/01/rdf-schema#comment | "External mechanical loading on a wound commonly increases fibrosis. Transforming growth factor-β1 (TGF-β1) has been implicated in fibrosis in various models, including the mechanical force model. However, the underlying mechanism is unclear. Our previous experiments suggested that eukaryotic initiation factor 6 (eIF6) acted as a regulator of TGF-β1 expression, and negatively impact on collagen synthesis. Our current results showed that external mechanical stretching significantly increased COL1A1, TGF-β1 and eIF6 expression as well as dermal fibroblasts proliferation, both in vitro and in vivo. eIF6 -deficient (eIF6+/-) cells exhibited significantly higher levels of COL1A1, and these levels increased further with external mechanical stretching, suggesting that mechanical stretching plays a synergistic role in promoting COL1A1 expression in eIF6+/- cells. Inhibition of TGFβR I/II by LY2109761 decreased COL1A1 protein expression in eIF6+/- dermal fibroblasts in a cell stretching model, and attenuated granulation tissue formation in partial thickness wounds of eIF6+/- mice. These data suggest that mechanical stretching has a synergistic role in the expression of COL1A1 in eIF6+/- cells, and is mediated by activation of TGFβRI/II. Taken together, our results indicate that eIF6 may be involved in external mechanical force-mediated murine dermal fibroblast function at least partly through the TGF-β1 pathway."xsd:string |
| http://purl.uniprot.org/citations/27824055 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep36075"xsd:string |
| http://purl.uniprot.org/citations/27824055 | http://purl.uniprot.org/core/author | "Hu X."xsd:string |
| http://purl.uniprot.org/citations/27824055 | http://purl.uniprot.org/core/author | "Luo G."xsd:string |
| http://purl.uniprot.org/citations/27824055 | http://purl.uniprot.org/core/author | "Tan J."xsd:string |
| http://purl.uniprot.org/citations/27824055 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/27824055 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/27824055 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/27824055 | http://purl.uniprot.org/core/author | "Yang S."xsd:string |
| http://purl.uniprot.org/citations/27824055 | http://purl.uniprot.org/core/author | "He W."xsd:string |
| http://purl.uniprot.org/citations/27824055 | http://purl.uniprot.org/core/author | "Shu Q."xsd:string |
| http://purl.uniprot.org/citations/27824055 | http://purl.uniprot.org/core/author | "Ulrike V.D."xsd:string |
| http://purl.uniprot.org/citations/27824055 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27824055 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/27824055 | http://purl.uniprot.org/core/pages | "36075"xsd:string |
| http://purl.uniprot.org/citations/27824055 | http://purl.uniprot.org/core/title | "Involvement of eIF6 in external mechanical stretch-mediated murine dermal fibroblast function via TGF-beta1 pathway."xsd:string |
| http://purl.uniprot.org/citations/27824055 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/27824055 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27824055 |
| http://purl.uniprot.org/citations/27824055 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27824055 |
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| http://purl.uniprot.org/uniprot/#_Q3U740-mappedCitation-27824055 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27824055 |