| http://purl.uniprot.org/citations/27825654 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27825654 | http://www.w3.org/2000/01/rdf-schema#comment | "The regulation of macrophage orientation pathological conditions is important but still incompletely understood. Here, we show that IL-10 and Rag1 double knockout mice spontaneously develop colitis with dominant M1 macrophage phenotype, suggesting that IL-10 regulates macrophage orientation in inflammation. We demonstrate that IL-10 stimulation induced miR-146b expression, and that the expression of miR-146b was impaired in IL-10 deficient macrophages. Our data show that miR-146b targets IRF5, resulting in the regulation of macrophage activation. Furthermore, miR-146b deficient mice developed intestinal inflammation with enhanced M1 macrophage polarization. Finally, miR-146b mimic treatment significantly suppresses M1 macrophage activation and ameliorates colitis development in vivo. Collectively, the results suggest that IL-10 dependent miR-146b plays an important role in the modulation of M1 macrophage orientation."xsd:string |
| http://purl.uniprot.org/citations/27825654 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ebiom.2016.10.041"xsd:string |
| http://purl.uniprot.org/citations/27825654 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/27825654 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/27825654 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/27825654 | http://purl.uniprot.org/core/author | "Lu G."xsd:string |
| http://purl.uniprot.org/citations/27825654 | http://purl.uniprot.org/core/author | "Peng L."xsd:string |
| http://purl.uniprot.org/citations/27825654 | http://purl.uniprot.org/core/author | "Hao Y."xsd:string |
| http://purl.uniprot.org/citations/27825654 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/27825654 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/27825654 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/27825654 | http://purl.uniprot.org/core/author | "Xiong H."xsd:string |
| http://purl.uniprot.org/citations/27825654 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/27825654 | http://purl.uniprot.org/core/author | "Zhang R."xsd:string |
| http://purl.uniprot.org/citations/27825654 | http://purl.uniprot.org/core/author | "Zheng Z."xsd:string |
| http://purl.uniprot.org/citations/27825654 | http://purl.uniprot.org/core/author | "Xu F."xsd:string |
| http://purl.uniprot.org/citations/27825654 | http://purl.uniprot.org/core/author | "Cui M."xsd:string |
| http://purl.uniprot.org/citations/27825654 | http://purl.uniprot.org/core/author | "Pierce S."xsd:string |
| http://purl.uniprot.org/citations/27825654 | http://purl.uniprot.org/core/author | "Qi C.F."xsd:string |
| http://purl.uniprot.org/citations/27825654 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27825654 | http://purl.uniprot.org/core/name | "EBioMedicine"xsd:string |
| http://purl.uniprot.org/citations/27825654 | http://purl.uniprot.org/core/pages | "83-96"xsd:string |
| http://purl.uniprot.org/citations/27825654 | http://purl.uniprot.org/core/title | "Reprogramming macrophage orientation by microRNA 146b targeting transcription factor IRF5."xsd:string |
| http://purl.uniprot.org/citations/27825654 | http://purl.uniprot.org/core/volume | "14"xsd:string |