| http://purl.uniprot.org/citations/27828963 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27828963 | http://www.w3.org/2000/01/rdf-schema#comment | "E-type cyclins (cyclins E1 and E2) are components of the cell cycle machinery that has been conserved from yeast to humans. The major function of E-type cyclins is to drive cell division. It is unknown whether in addition to their 'core' cell cycle functions, E-type cyclins also perform unique tissue-specific roles. Here, we applied high-throughput mass spectrometric analyses of mouse organs to define the repertoire of cyclin E protein partners in vivo. We found that cyclin E interacts with distinct sets of proteins in different compartments. These cyclin E interactors are highly enriched for phosphorylation targets of cyclin E and its catalytic partner, the cyclin-dependent kinase 2 (Cdk2). Among cyclin E interactors we identified several novel tissue-specific substrates of cyclin E-Cdk2 kinase. In proliferating compartments, cyclin E-Cdk2 phosphorylates Lin proteins within the DREAM complex. In the testes, cyclin E-Cdk2 phosphorylates Mybl1 and Dmrtc2, two meiotic transcription factors that represent key regulators of spermatogenesis. In embryonic and adult brains cyclin E interacts with proteins involved in neurogenesis, while in adult brains also with proteins regulating microtubule-based processes and microtubule cytoskeleton. We also used quantitative proteomics to demonstrate re-wiring of the cyclin E interactome upon ablation of Cdk2. This approach can be used to study how protein interactome changes during development or in any pathological state such as aging or cancer."xsd:string |
| http://purl.uniprot.org/citations/27828963 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1006429"xsd:string |
| http://purl.uniprot.org/citations/27828963 | http://purl.uniprot.org/core/author | "DeCaprio J.A."xsd:string |
| http://purl.uniprot.org/citations/27828963 | http://purl.uniprot.org/core/author | "Geng Y."xsd:string |
| http://purl.uniprot.org/citations/27828963 | http://purl.uniprot.org/core/author | "Marco E."xsd:string |
| http://purl.uniprot.org/citations/27828963 | http://purl.uniprot.org/core/author | "Litovchick L."xsd:string |
| http://purl.uniprot.org/citations/27828963 | http://purl.uniprot.org/core/author | "Wang Y.E."xsd:string |
| http://purl.uniprot.org/citations/27828963 | http://purl.uniprot.org/core/author | "Saini S."xsd:string |
| http://purl.uniprot.org/citations/27828963 | http://purl.uniprot.org/core/author | "Sicinski P."xsd:string |
| http://purl.uniprot.org/citations/27828963 | http://purl.uniprot.org/core/author | "Odajima J."xsd:string |
| http://purl.uniprot.org/citations/27828963 | http://purl.uniprot.org/core/author | "Michowski W."xsd:string |
| http://purl.uniprot.org/citations/27828963 | http://purl.uniprot.org/core/author | "Jung P."xsd:string |
| http://purl.uniprot.org/citations/27828963 | http://purl.uniprot.org/core/author | "Marto J."xsd:string |
| http://purl.uniprot.org/citations/27828963 | http://purl.uniprot.org/core/author | "Ficaro S."xsd:string |
| http://purl.uniprot.org/citations/27828963 | http://purl.uniprot.org/core/author | "Ndassa-Colday Y."xsd:string |
| http://purl.uniprot.org/citations/27828963 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27828963 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/27828963 | http://purl.uniprot.org/core/pages | "e1006429"xsd:string |
| http://purl.uniprot.org/citations/27828963 | http://purl.uniprot.org/core/title | "Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo."xsd:string |
| http://purl.uniprot.org/citations/27828963 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/27828963 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27828963 |
| http://purl.uniprot.org/citations/27828963 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27828963 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RNE6-mappedCitation-27828963 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27828963 |
| http://purl.uniprot.org/uniprot/#_A2API1-mappedCitation-27828963 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27828963 |