| http://purl.uniprot.org/citations/27829368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27829368 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundThe AP-2 transcription factor APTF-1 is crucially required for developmentally controlled sleep behavior in Caenorhabditis elegans larvae. Its human ortholog, TFAP-2beta, causes Char disease and has also been linked to sleep disorders. These data suggest that AP-2 transcription factors may be highly conserved regulators of various types of sleep behavior. Here, we tested the idea that AP-2 controls adult sleep in Drosophila.ResultsDrosophila has one AP-2 ortholog called TfAP-2, which is essential for viability. To investigate its potential role in sleep behavior and neural development, we specifically downregulated TfAP-2 in the nervous system. We found that neuronal TfAP-2 knockdown almost completely abolished night sleep but did not affect day sleep. TfAP-2 insufficiency affected nervous system development. Conditional TfAP-2 knockdown in the adult also produced a modest sleep phenotype, suggesting that TfAP-2 acts both in larval as well as in differentiated neurons.ConclusionsThus, our results show that AP-2 transcription factors are highly conserved regulators of development and sleep."xsd:string |
| http://purl.uniprot.org/citations/27829368 | http://purl.org/dc/terms/identifier | "doi:10.1186/s12868-016-0306-3"xsd:string |
| http://purl.uniprot.org/citations/27829368 | http://purl.uniprot.org/core/author | "Bringmann H."xsd:string |
| http://purl.uniprot.org/citations/27829368 | http://purl.uniprot.org/core/author | "Herzig B."xsd:string |
| http://purl.uniprot.org/citations/27829368 | http://purl.uniprot.org/core/author | "Kucherenko M.M."xsd:string |
| http://purl.uniprot.org/citations/27829368 | http://purl.uniprot.org/core/author | "Shcherbata H.R."xsd:string |
| http://purl.uniprot.org/citations/27829368 | http://purl.uniprot.org/core/author | "Ilangovan V."xsd:string |
| http://purl.uniprot.org/citations/27829368 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27829368 | http://purl.uniprot.org/core/name | "BMC Neurosci"xsd:string |
| http://purl.uniprot.org/citations/27829368 | http://purl.uniprot.org/core/pages | "72"xsd:string |
| http://purl.uniprot.org/citations/27829368 | http://purl.uniprot.org/core/title | "TfAP-2 is required for night sleep in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/27829368 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/27829368 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27829368 |
| http://purl.uniprot.org/citations/27829368 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27829368 |
| http://purl.uniprot.org/uniprot/M9PIH9#attribution-B8BC038AFF9C0A25AC54268B39B5EF2B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27829368 |
| http://purl.uniprot.org/uniprot/#_A1Z6N2-mappedCitation-27829368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27829368 |
| http://purl.uniprot.org/uniprot/#_O96378-mappedCitation-27829368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27829368 |
| http://purl.uniprot.org/uniprot/#_M9PFX8-mappedCitation-27829368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27829368 |
| http://purl.uniprot.org/uniprot/#_M9PG57-mappedCitation-27829368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27829368 |
| http://purl.uniprot.org/uniprot/#_M9PD85-mappedCitation-27829368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27829368 |
| http://purl.uniprot.org/uniprot/#_O76923-mappedCitation-27829368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27829368 |
| http://purl.uniprot.org/uniprot/#_M9PIH9-mappedCitation-27829368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27829368 |
| http://purl.uniprot.org/uniprot/#_Q8MZ32-mappedCitation-27829368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27829368 |
| http://purl.uniprot.org/uniprot/#_Q9VIQ0-mappedCitation-27829368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27829368 |