| http://purl.uniprot.org/citations/27834869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27834869 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs are a class of small non-coding RNAs that bind to the three prime untranslated region (3'-UTR) of target mRNAs. They cause a cleavage or an inhibition of the translation of target mRNAs, thus regulating gene expression. Here, we employed three prediction tools to search for potential miRNA target sites in the 3'-UTR of the human platelet glycoprotein (GP) 1BA gene. A luciferase reporter assay shows that miR-10a and -10b sites are functional. When miR-10a or -10b mimics were transfected into the GP Ibβ/GP IX-expressing cells, along with a DNA construct harboring both the coding and 3'-UTR sequences of the human GP1BA gene, we found that they inhibit the transient expression of GP Ibα on the cell surface. When the miR-10a or -10b mimics were introduced into murine progenitor cells, upon megakaryocyte differentiation, we found that GP Ibα mRNA expression was markedly reduced, suggesting that a miRNA-induced mRNA degradation is at work. Thus, our study identifies GP Ibα as a novel target of miR-10a and -10b, suggesting that a drastic reduction in the levels of miR-10a and -10b in the late stage of megakaryopoiesis is required to allow the expression of human GP Ibα and the formation of the GP Ib-IX-V complex."xsd:string |
| http://purl.uniprot.org/citations/27834869 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms17111873"xsd:string |
| http://purl.uniprot.org/citations/27834869 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/27834869 | http://purl.uniprot.org/core/author | "Ran Y."xsd:string |
| http://purl.uniprot.org/citations/27834869 | http://purl.uniprot.org/core/author | "Peng Y."xsd:string |
| http://purl.uniprot.org/citations/27834869 | http://purl.uniprot.org/core/author | "Shaw T.S."xsd:string |
| http://purl.uniprot.org/citations/27834869 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27834869 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/27834869 | http://purl.uniprot.org/core/pages | "E1873"xsd:string |
| http://purl.uniprot.org/citations/27834869 | http://purl.uniprot.org/core/title | "MicroRNAs 10a and 10b Regulate the Expression of Human Platelet Glycoprotein Ibalpha for Normal Megakaryopoiesis."xsd:string |
| http://purl.uniprot.org/citations/27834869 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/27834869 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27834869 |
| http://purl.uniprot.org/citations/27834869 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27834869 |
| http://purl.uniprot.org/uniprot/#_A0A193AU54-mappedCitation-27834869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27834869 |
| http://purl.uniprot.org/uniprot/#_A0A193AUC0-mappedCitation-27834869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27834869 |
| http://purl.uniprot.org/uniprot/#_A0A193AUJ5-mappedCitation-27834869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27834869 |
| http://purl.uniprot.org/uniprot/#_A0A193AUV8-mappedCitation-27834869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27834869 |
| http://purl.uniprot.org/uniprot/#_E0D851-mappedCitation-27834869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27834869 |
| http://purl.uniprot.org/uniprot/#_E0D852-mappedCitation-27834869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27834869 |
| http://purl.uniprot.org/uniprot/#_A5CKE2-mappedCitation-27834869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27834869 |
| http://purl.uniprot.org/uniprot/#_A0A140GX60-mappedCitation-27834869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27834869 |
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| http://purl.uniprot.org/uniprot/#_A0A140GX63-mappedCitation-27834869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27834869 |