DESCRIBE <http://purl.uniprot.org/citations/27836114>

Subject	Predicate	Object
http://purl.uniprot.org/citations/27836114	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/27836114	http://www.w3.org/2000/01/rdf-schema#comment	" Introduction and objectives Recent research has suggested that genetic factors may play an important role in the development of drug resistance in epilepsy. It is not clear which gene loci are responsible for the drug-resistant phenotype. Studying certain nuclear receptors may be helpful in predicting drug response, as they regulate drug transporting proteins and enzymes involved in their metabolism. This study focuses on one of these receptors, the human pregnane X receptor (hPXR). The objective was to examine the link between selected single nucleotide polymorphisms (SNPs) 69789A/G rs 7643645 and 66034T/C rs 13059232 hPXR and the lack of response to epilepsy treatment. Materials and methods 73 patients diagnosed with drug-resistant epilepsy were included in the study. The diagnoses were made according to the criteria published by The International League Against Epilepsy (ILAE) in 2010. The control group was comprised of a group of 122 healthy volunteers. Genetic material isolated from the peripheral blood of the participants was analyzed with TagMan Genotyping Assays in search of the selected hPXR polymorphisms. Results The distribution of genotypes of the 66034T/C rs 13059232 hPXR polymorphism was significantly different in the group with drug-resistant epilepsy and the control group. In the drug-resistant group the CC genotype was significantly more common compared to the control group (50.7% vs 35.2%) p=0.0339. The distribution of 69789 A/G rs 7643645 hPXR genotypes was comparable in both groups. Conclusions There is potential association between hPXR and drug resistance but its relevance for the development of drug-resistant phenotype remains to be studied."xsd:string
http://purl.uniprot.org/citations/27836114	http://purl.org/dc/terms/identifier	"doi:10.1016/j.pjnns.2016.10.002"xsd:string
http://purl.uniprot.org/citations/27836114	http://purl.uniprot.org/core/author	"Jastrzebski K."xsd:string
http://purl.uniprot.org/citations/27836114	http://purl.uniprot.org/core/author	"Klimek A."xsd:string
http://purl.uniprot.org/citations/27836114	http://purl.uniprot.org/core/author	"Glabinski A."xsd:string
http://purl.uniprot.org/citations/27836114	http://purl.uniprot.org/core/author	"Kozera-Kepniak A."xsd:string
http://purl.uniprot.org/citations/27836114	http://purl.uniprot.org/core/author	"Walenczak J."xsd:string
http://purl.uniprot.org/citations/27836114	http://purl.uniprot.org/core/date	"2017"xsd:gYear
http://purl.uniprot.org/citations/27836114	http://purl.uniprot.org/core/name	"Neurol Neurochir Pol"xsd:string
http://purl.uniprot.org/citations/27836114	http://purl.uniprot.org/core/pages	"19-23"xsd:string
http://purl.uniprot.org/citations/27836114	http://purl.uniprot.org/core/title	"66034T/C polymorphism of the human pregnane X receptor (hPXR) as potential risk factor for drug resistance in epilepsy - Preliminary study."xsd:string
http://purl.uniprot.org/citations/27836114	http://purl.uniprot.org/core/volume	"51"xsd:string
http://purl.uniprot.org/citations/27836114	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/27836114
http://purl.uniprot.org/citations/27836114	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/27836114
http://purl.uniprot.org/uniprot/#_B3KVM5-mappedCitation-27836114	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27836114
http://purl.uniprot.org/uniprot/#_B6ZGT1-mappedCitation-27836114	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27836114
http://purl.uniprot.org/uniprot/#_F1D8P9-mappedCitation-27836114	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27836114
http://purl.uniprot.org/uniprot/#_F1DAL3-mappedCitation-27836114	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27836114
http://purl.uniprot.org/uniprot/#_H0Y8E2-mappedCitation-27836114	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27836114
http://purl.uniprot.org/uniprot/#_J3KPQ3-mappedCitation-27836114	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27836114
http://purl.uniprot.org/uniprot/#_O75469-mappedCitation-27836114	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27836114
http://purl.uniprot.org/uniprot/#_Q9H4M8-mappedCitation-27836114	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/27836114
http://purl.uniprot.org/uniprot/F1DAL3	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/27836114
http://purl.uniprot.org/uniprot/J3KPQ3	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/27836114