| http://purl.uniprot.org/citations/27837104 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27837104 | http://www.w3.org/2000/01/rdf-schema#comment | "Patients with systemic lupus erythematosus exhibit accelerated atherosclerosis, a chronic inflammatory disease of the arterial wall. The impact of B cells in atherosclerosis is controversial, with both protective and pathogenic roles described. For example, natural IgM binding conserved oxidized lipid epitopes protect against atherosclerosis, whereas anti-oxidized low-density lipoprotein (oxLDL) IgG likely promotes disease. Because BAFF promotes B cell class-switch recombination and humoral autoimmunity, we hypothesized that excess BAFF would accelerate atherosclerosis. In contrast, BAFF overexpression markedly reduced hypercholesterolemia and atherosclerosis in hyperlipidemic mice. BAFF-mediated atheroprotection required B cells and was associated with increased protective anti-oxLDL IgM. Surprisingly, high-titer anti-oxLDL IgM production and reduced atherosclerosis was dependent on the BAFF family receptor transmembrane activator and CAML interactor. In summary, we identified a novel role for B cell-specific, BAFF-dependent transmembrane activator and CAML interactor signals in atherosclerosis pathogenesis, of particular relevance to the use of BAFF-targeted therapies in systemic lupus erythematosus."xsd:string |
| http://purl.uniprot.org/citations/27837104 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1601198"xsd:string |
| http://purl.uniprot.org/citations/27837104 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/27837104 | http://purl.uniprot.org/core/author | "Rawlings D.J."xsd:string |
| http://purl.uniprot.org/citations/27837104 | http://purl.uniprot.org/core/author | "Jacobs H.M."xsd:string |
| http://purl.uniprot.org/citations/27837104 | http://purl.uniprot.org/core/author | "Jackson S.W."xsd:string |
| http://purl.uniprot.org/citations/27837104 | http://purl.uniprot.org/core/author | "Chait A."xsd:string |
| http://purl.uniprot.org/citations/27837104 | http://purl.uniprot.org/core/author | "Scharping N.E."xsd:string |
| http://purl.uniprot.org/citations/27837104 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27837104 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/27837104 | http://purl.uniprot.org/core/pages | "4529-4534"xsd:string |
| http://purl.uniprot.org/citations/27837104 | http://purl.uniprot.org/core/title | "Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation."xsd:string |
| http://purl.uniprot.org/citations/27837104 | http://purl.uniprot.org/core/volume | "197"xsd:string |
| http://purl.uniprot.org/citations/27837104 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27837104 |
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| http://purl.uniprot.org/uniprot/#_A0A0U5J6R6-mappedCitation-27837104 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27837104 |
| http://purl.uniprot.org/uniprot/#_P49070-mappedCitation-27837104 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27837104 |
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