| http://purl.uniprot.org/citations/27840026 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27840026 | http://www.w3.org/2000/01/rdf-schema#comment | "For many years, a connection between circadian clocks and cancer has been postulated. Here we describe an unexpected function for the circadian repressor CRY2 as a component of an FBXL3-containing E3 ligase that recruits T58-phosphorylated c-MYC for ubiquitylation. c-MYC is a critical regulator of cell proliferation; T58 is central in a phosphodegron long recognized as a hotspot for mutation in cancer. This site is also targeted by FBXW7, although the full machinery responsible for its turnover has remained obscure. CRY1 cannot substitute for CRY2 in promoting c-MYC degradation. Their unique functions may explain prior conflicting reports that have fueled uncertainty about the relationship between clocks and cancer. We demonstrate that c-MYC is a target of CRY2-dependent protein turnover, suggesting a molecular mechanism for circadian control of cell growth and a new paradigm for circadian protein degradation."xsd:string |
| http://purl.uniprot.org/citations/27840026 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2016.10.012"xsd:string |
| http://purl.uniprot.org/citations/27840026 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/27840026 | http://purl.uniprot.org/core/author | "Nguyen M."xsd:string |
| http://purl.uniprot.org/citations/27840026 | http://purl.uniprot.org/core/author | "Lamia K.A."xsd:string |
| http://purl.uniprot.org/citations/27840026 | http://purl.uniprot.org/core/author | "Henriksson E."xsd:string |
| http://purl.uniprot.org/citations/27840026 | http://purl.uniprot.org/core/author | "Chan A.B."xsd:string |
| http://purl.uniprot.org/citations/27840026 | http://purl.uniprot.org/core/author | "Huber A.L."xsd:string |
| http://purl.uniprot.org/citations/27840026 | http://purl.uniprot.org/core/author | "Jordan S.D."xsd:string |
| http://purl.uniprot.org/citations/27840026 | http://purl.uniprot.org/core/author | "Kriebs A."xsd:string |
| http://purl.uniprot.org/citations/27840026 | http://purl.uniprot.org/core/author | "Papp S.J."xsd:string |
| http://purl.uniprot.org/citations/27840026 | http://purl.uniprot.org/core/author | "Wallace M."xsd:string |
| http://purl.uniprot.org/citations/27840026 | http://purl.uniprot.org/core/author | "Metallo C.M."xsd:string |
| http://purl.uniprot.org/citations/27840026 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27840026 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/27840026 | http://purl.uniprot.org/core/pages | "774-789"xsd:string |
| http://purl.uniprot.org/citations/27840026 | http://purl.uniprot.org/core/title | "CRY2 and FBXL3 Cooperatively Degrade c-MYC."xsd:string |
| http://purl.uniprot.org/citations/27840026 | http://purl.uniprot.org/core/volume | "64"xsd:string |
| http://purl.uniprot.org/citations/27840026 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27840026 |
| http://purl.uniprot.org/citations/27840026 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27840026 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-27840026 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27840026 |
| http://purl.uniprot.org/uniprot/#_A0A0D2X7Z3-mappedCitation-27840026 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27840026 |
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| http://purl.uniprot.org/uniprot/#_E0CZD1-mappedCitation-27840026 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27840026 |