| http://purl.uniprot.org/citations/2784196 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2784196 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2784196 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytotoxic T lymphocytes (CTL) expressing the CD8 glycoprotein recognize peptide antigens presented by class I major histocompatibility complex (MHC) molecules. This correlation and the absence of CD8 polymorphism led to the hypothesis that CD8 binds to a conserved site of class I MHC molecules. Using a cell-cell binding assay we previously demonstrated specific interaction between human class I MHC (HLA-A,B,C) molecules and CD8. Subsequent analysis of the products of 17 HLA-A,B alleles revealed a natural polymorphism for CD8 binding in the human population. Two molecules, HLA-Aw68.1 and HLA-Aw68.2, which do not bind CD8, have a valine residue at position 245 whereas all other HLA-A,B,C molecules have alanine. Site-directed mutagenesis shows that this single substitution in the alpha 3 domain is responsible for the CD8 binding phenotype and also affects recognition by alloreactive and influenza-specific CTL. Our results indicate that CD8 binds to the alpha 3 domain of class I MHC molecules."xsd:string |
| http://purl.uniprot.org/citations/2784196 | http://purl.org/dc/terms/identifier | "doi:10.1038/338345a0"xsd:string |
| http://purl.uniprot.org/citations/2784196 | http://purl.org/dc/terms/identifier | "doi:10.1038/338345a0"xsd:string |
| http://purl.uniprot.org/citations/2784196 | http://purl.uniprot.org/core/author | "Parham P."xsd:string |
| http://purl.uniprot.org/citations/2784196 | http://purl.uniprot.org/core/author | "Parham P."xsd:string |
| http://purl.uniprot.org/citations/2784196 | http://purl.uniprot.org/core/author | "Littman D.R."xsd:string |
| http://purl.uniprot.org/citations/2784196 | http://purl.uniprot.org/core/author | "Littman D.R."xsd:string |
| http://purl.uniprot.org/citations/2784196 | http://purl.uniprot.org/core/author | "Clayberger C."xsd:string |
| http://purl.uniprot.org/citations/2784196 | http://purl.uniprot.org/core/author | "Clayberger C."xsd:string |
| http://purl.uniprot.org/citations/2784196 | http://purl.uniprot.org/core/author | "Salter R.D."xsd:string |
| http://purl.uniprot.org/citations/2784196 | http://purl.uniprot.org/core/author | "Salter R.D."xsd:string |
| http://purl.uniprot.org/citations/2784196 | http://purl.uniprot.org/core/author | "Chen B.P."xsd:string |
| http://purl.uniprot.org/citations/2784196 | http://purl.uniprot.org/core/author | "Chen B.P."xsd:string |
| http://purl.uniprot.org/citations/2784196 | http://purl.uniprot.org/core/author | "Krensky A.M."xsd:string |
| http://purl.uniprot.org/citations/2784196 | http://purl.uniprot.org/core/author | "Krensky A.M."xsd:string |
| http://purl.uniprot.org/citations/2784196 | http://purl.uniprot.org/core/author | "Norment A.M."xsd:string |
| http://purl.uniprot.org/citations/2784196 | http://purl.uniprot.org/core/author | "Norment A.M."xsd:string |
| http://purl.uniprot.org/citations/2784196 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2784196 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2784196 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/2784196 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/2784196 | http://purl.uniprot.org/core/pages | "345-347"xsd:string |
| http://purl.uniprot.org/citations/2784196 | http://purl.uniprot.org/core/pages | "345-347"xsd:string |