| http://purl.uniprot.org/citations/27845622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27845622 | http://www.w3.org/2000/01/rdf-schema#comment | "The balance between self-renewal and differentiation of neural progenitor cells (NPCs) dictates neurogenesis and proper brain development. We found that the RNA-binding protein Sam68 (Khdrbs1) is strongly expressed in neurogenic areas of the neocortex and supports the self-renewing potential of mouse NPCs. Knockout of Khdrbs1 constricted the pool of proliferating NPCs by accelerating their cell cycle exit and differentiation into post-mitotic neurons. Sam68 function was linked to regulation of Aldh1a3 pre-mRNA 3'-end processing. Binding of Sam68 to an intronic polyadenylation site prevents its recognition and premature transcript termination, favoring expression of a functional enzyme. The lower ALDH1A3 expression and activity in Khdrbs1-/- NPCs results in reduced glycolysis and clonogenicity, thus depleting the embryonic NPC pool and limiting cortical expansion. Our study identifies Sam68 as a key regulator of NPC self-renewal and establishes a novel link between modulation of ALDH1A3 expression and maintenance of high glycolytic metabolism in the developing cortex."xsd:string |
| http://purl.uniprot.org/citations/27845622 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.20750"xsd:string |
| http://purl.uniprot.org/citations/27845622 | http://purl.uniprot.org/core/author | "Bielli P."xsd:string |
| http://purl.uniprot.org/citations/27845622 | http://purl.uniprot.org/core/author | "Volpe E."xsd:string |
| http://purl.uniprot.org/citations/27845622 | http://purl.uniprot.org/core/author | "Sette C."xsd:string |
| http://purl.uniprot.org/citations/27845622 | http://purl.uniprot.org/core/author | "La Rosa P."xsd:string |
| http://purl.uniprot.org/citations/27845622 | http://purl.uniprot.org/core/author | "Compagnucci C."xsd:string |
| http://purl.uniprot.org/citations/27845622 | http://purl.uniprot.org/core/author | "Cesari E."xsd:string |
| http://purl.uniprot.org/citations/27845622 | http://purl.uniprot.org/core/author | "Farioli Vecchioli S."xsd:string |
| http://purl.uniprot.org/citations/27845622 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27845622 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/27845622 | http://purl.uniprot.org/core/pages | "e20750"xsd:string |
| http://purl.uniprot.org/citations/27845622 | http://purl.uniprot.org/core/title | "Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing."xsd:string |
| http://purl.uniprot.org/citations/27845622 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/27845622 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27845622 |
| http://purl.uniprot.org/citations/27845622 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27845622 |
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| http://purl.uniprot.org/uniprot/#_A2A412-mappedCitation-27845622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27845622 |
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| http://purl.uniprot.org/uniprot/#_F6VSW9-mappedCitation-27845622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27845622 |