| http://purl.uniprot.org/citations/2784591 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2784591 | http://www.w3.org/2000/01/rdf-schema#comment | "The murine IL-4 and IL-5 genes encode hemopoietic growth factors involved in the stimulation, proliferation, and differentiation of cells of the T lymphocyte, B lymphocyte, and granulocyte lineages. We have mapped the Il-4 and Il-5 loci representing the structural genes for IL-4 and IL-5, respectively, to mouse chromosome 11 using Chinese hamster x mouse and rat x mouse somatic cell hybrids. Physical linkage studies of the IL-4 and IL-5 genes by pulsed field gel electrophoresis have shown that they are closely linked, being 110-180 kb apart. Since the Il-5 locus maps to the interface of bands A5 and B1 in the same location as the genes for IL-3 and GM-CSF, this places these three cytokine genes, as well as the IL-4 gene, within a region of about 5000-10,000 kb. The present physical linkage studies indicate that the IL-4 and IL-5 genes are a minimum of 600 kb apart from the closely linked IL-3 and GM-CSF genes. The gene clustering, together with similarities in gene structure, regulation, and biological function, raises the possibility that the four genes may be part of a distantly related cytokine gene family."xsd:string |
| http://purl.uniprot.org/citations/2784591 | http://purl.org/dc/terms/identifier | "doi:10.1007/bf01535075"xsd:string |
| http://purl.uniprot.org/citations/2784591 | http://purl.uniprot.org/core/author | "Lee J.S."xsd:string |
| http://purl.uniprot.org/citations/2784591 | http://purl.uniprot.org/core/author | "Kozak C.A."xsd:string |
| http://purl.uniprot.org/citations/2784591 | http://purl.uniprot.org/core/author | "Campbell H.D."xsd:string |
| http://purl.uniprot.org/citations/2784591 | http://purl.uniprot.org/core/author | "Young I.G."xsd:string |
| http://purl.uniprot.org/citations/2784591 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2784591 | http://purl.uniprot.org/core/name | "Somat Cell Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/2784591 | http://purl.uniprot.org/core/pages | "143-152"xsd:string |
| http://purl.uniprot.org/citations/2784591 | http://purl.uniprot.org/core/title | "The IL-4 and IL-5 genes are closely linked and are part of a cytokine gene cluster on mouse chromosome 11."xsd:string |
| http://purl.uniprot.org/citations/2784591 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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