| http://purl.uniprot.org/citations/27849571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27849571 | http://www.w3.org/2000/01/rdf-schema#comment | "Quiescent muscle stem cells (MSCs) become activated in response to skeletal muscle injury to initiate regeneration. Activated MSCs proliferate and differentiate to repair damaged fibers or self-renew to maintain the pool and ensure future regeneration. The balance between self-renewal, proliferation, and differentiation is a tightly regulated process controlled by a genetic cascade involving determinant transcription factors such as Pax7, Myf5, MyoD, and MyoG. Recently, there have been several reports about the role of arginine methylation as a requirement for epigenetically mediated control of muscle regeneration. Here we report that the protein arginine methyltransferase 1 (PRMT1) is expressed in MSCs and that conditional ablation of PRMT1 in MSCs using Pax7CreERT2 causes impairment of muscle regeneration. Importantly, PRMT1-deficient MSCs have enhanced cell proliferation after injury but are unable to terminate the myogenic differentiation program, leading to regeneration failure. We identify the coactivator of Six1, Eya1, as a substrate of PRMT1. We show that PRMT1 methylates Eya1 in vitro and that loss of PRMT1 function in vivo prevents Eya1 methylation. Moreover, we observe that PRMT1-deficient MSCs have reduced expression of Eya1/Six1 target MyoD due to disruption of Eya1 recruitment at the MyoD promoter and subsequent Eya1-mediated coactivation. These findings suggest that arginine methylation by PRMT1 regulates muscle stem cell fate through the Eya1/Six1/MyoD axis."xsd:string |
| http://purl.uniprot.org/citations/27849571 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00457-16"xsd:string |
| http://purl.uniprot.org/citations/27849571 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/27849571 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/27849571 | http://purl.uniprot.org/core/author | "Yu Z."xsd:string |
| http://purl.uniprot.org/citations/27849571 | http://purl.uniprot.org/core/author | "Richard S."xsd:string |
| http://purl.uniprot.org/citations/27849571 | http://purl.uniprot.org/core/author | "Vogel G."xsd:string |
| http://purl.uniprot.org/citations/27849571 | http://purl.uniprot.org/core/author | "Blanc R.S."xsd:string |
| http://purl.uniprot.org/citations/27849571 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27849571 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/27849571 | http://purl.uniprot.org/core/pages | "e00457-16"xsd:string |
| http://purl.uniprot.org/citations/27849571 | http://purl.uniprot.org/core/title | "Arginine Methylation by PRMT1 Regulates Muscle Stem Cell Fate."xsd:string |
| http://purl.uniprot.org/citations/27849571 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/27849571 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27849571 |
| http://purl.uniprot.org/citations/27849571 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27849571 |
| http://purl.uniprot.org/uniprot/#_A0A140LHF7-mappedCitation-27849571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27849571 |
| http://purl.uniprot.org/uniprot/#_A0A140LHS4-mappedCitation-27849571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27849571 |
| http://purl.uniprot.org/uniprot/#_A0A140LI33-mappedCitation-27849571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27849571 |
| http://purl.uniprot.org/uniprot/#_A0A140LIF7-mappedCitation-27849571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27849571 |
| http://purl.uniprot.org/uniprot/#_A0A140LJ68-mappedCitation-27849571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27849571 |
| http://purl.uniprot.org/uniprot/#_A0A140LJ70-mappedCitation-27849571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27849571 |
| http://purl.uniprot.org/uniprot/#_A0A140LJF4-mappedCitation-27849571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27849571 |
| http://purl.uniprot.org/uniprot/#_A0A140LJG1-mappedCitation-27849571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27849571 |
| http://purl.uniprot.org/uniprot/#_A0A171KXD3-mappedCitation-27849571 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27849571 |