| http://purl.uniprot.org/citations/27851910 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27851910 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of the innate immune response in Metazoans is initiated through the recognition of microbes by host pattern-recognition receptors. In Drosophila, diaminopimelic acid (DAP)-containing peptidoglycan from Gram-negative bacteria is detected by the transmembrane receptor PGRP-LC and by the intracellular receptor PGRP-LE. Here, we show that PGRP-SD acted upstream of PGRP-LC as an extracellular receptor to enhance peptidoglycan-mediated activation of Imd signaling. Consistent with this, PGRP-SD mutants exhibited impaired activation of the Imd pathway and increased susceptibility to DAP-type bacteria. PGRP-SD enhanced the localization of peptidoglycans to the cell surface and hence promoted signaling. Moreover, PGRP-SD antagonized the action of PGRP-LB, an extracellular negative regulator, to fine-tune the intensity of the immune response. These data reveal that Drosophila PGRP-SD functions as an extracellular receptor similar to mammalian CD14 and demonstrate that, comparable to lipopolysaccharide sensing in mammals, Drosophila relies on both intra- and extracellular receptors for the detection of bacteria."xsd:string |
| http://purl.uniprot.org/citations/27851910 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2016.10.029"xsd:string |
| http://purl.uniprot.org/citations/27851910 | http://purl.uniprot.org/core/author | "Kondo S."xsd:string |
| http://purl.uniprot.org/citations/27851910 | http://purl.uniprot.org/core/author | "Lemaitre B."xsd:string |
| http://purl.uniprot.org/citations/27851910 | http://purl.uniprot.org/core/author | "Mengin-Lecreulx D."xsd:string |
| http://purl.uniprot.org/citations/27851910 | http://purl.uniprot.org/core/author | "Iatsenko I."xsd:string |
| http://purl.uniprot.org/citations/27851910 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27851910 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/27851910 | http://purl.uniprot.org/core/pages | "1013-1023"xsd:string |
| http://purl.uniprot.org/citations/27851910 | http://purl.uniprot.org/core/title | "PGRP-SD, an Extracellular Pattern-Recognition Receptor, Enhances Peptidoglycan-Mediated Activation of the Drosophila Imd Pathway."xsd:string |
| http://purl.uniprot.org/citations/27851910 | http://purl.uniprot.org/core/volume | "45"xsd:string |
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| http://purl.uniprot.org/citations/27851910 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27851910 |
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| http://purl.uniprot.org/uniprot/Q9VS97#attribution-DED6BB8B884F0FD38F1457E2F9DF9233 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/27851910 |
| http://purl.uniprot.org/uniprot/#_A0A0S0WMR4-mappedCitation-27851910 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27851910 |
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| http://purl.uniprot.org/uniprot/#_E1JI89-mappedCitation-27851910 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27851910 |