| http://purl.uniprot.org/citations/27851956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27851956 | http://www.w3.org/2000/01/rdf-schema#comment | "Distinct signaling pathways activate the NF-κB family of transcription factors. The canonical NF-κB-signaling pathway is mediated by IκB kinase 2/β (IKK2/β), while the non-canonical pathway depends on IKK1/α. The structural and biochemical bases for distinct signaling by these otherwise highly similar IKKs are unclear. We report single-particle cryoelectron microscopy (cryo-EM) and X-ray crystal structures of human IKK1 in dimeric (∼150 kDa) and hexameric (∼450 kDa) forms. The hexamer, which is the representative form in the crystal but comprises only ∼2% of the particles in solution by cryo-EM, is a trimer of IKK1 dimers. While IKK1 hexamers are not detectable in cells, the surface that supports hexamer formation is critical for IKK1-dependent cellular processing of p100 to p52, the hallmark of non-canonical NF-κB signaling. Comparison of this surface to that in IKK2 indicates significant divergence, and it suggests a fundamental role for this surface in signaling by these kinases through distinct pathways."xsd:string |
| http://purl.uniprot.org/citations/27851956 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2016.10.067"xsd:string |
| http://purl.uniprot.org/citations/27851956 | http://purl.uniprot.org/core/author | "Biswas T."xsd:string |
| http://purl.uniprot.org/citations/27851956 | http://purl.uniprot.org/core/author | "Verma I.M."xsd:string |
| http://purl.uniprot.org/citations/27851956 | http://purl.uniprot.org/core/author | "Ghosh G."xsd:string |
| http://purl.uniprot.org/citations/27851956 | http://purl.uniprot.org/core/author | "Passos D.O."xsd:string |
| http://purl.uniprot.org/citations/27851956 | http://purl.uniprot.org/core/author | "Lyumkis D."xsd:string |
| http://purl.uniprot.org/citations/27851956 | http://purl.uniprot.org/core/author | "Huang D.B."xsd:string |
| http://purl.uniprot.org/citations/27851956 | http://purl.uniprot.org/core/author | "Mulero M.C."xsd:string |
| http://purl.uniprot.org/citations/27851956 | http://purl.uniprot.org/core/author | "Mazumder A."xsd:string |
| http://purl.uniprot.org/citations/27851956 | http://purl.uniprot.org/core/author | "Polley S."xsd:string |
| http://purl.uniprot.org/citations/27851956 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/27851956 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/27851956 | http://purl.uniprot.org/core/pages | "1907-1914"xsd:string |
| http://purl.uniprot.org/citations/27851956 | http://purl.uniprot.org/core/title | "Structural Basis for the Activation of IKK1/alpha."xsd:string |
| http://purl.uniprot.org/citations/27851956 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/27851956 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27851956 |
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| http://purl.uniprot.org/uniprot/#_Q59GT1-mappedCitation-27851956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27851956 |
| http://purl.uniprot.org/uniprot/Q59GT1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27851956 |
| http://purl.uniprot.org/uniprot/Q562E6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27851956 |
| http://purl.uniprot.org/uniprot/O15111 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27851956 |