http://purl.uniprot.org/citations/27852059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/27852059 | http://www.w3.org/2000/01/rdf-schema#comment | "Avian leukosis virus subgroup J (ALV-J) is an oncogenic virus causing hemangiomas and myeloid tumors in chickens. Interleukin-6 (IL-6) is a multifunctional pro-inflammatory interleukin involved in many types of cancer. We previously demonstrated that IL-6 expression was induced following ALV-J infection in chickens. The aim of this study is to characterize the mechanism by which ALV-J induces IL-6 expression, and the role of IL-6 in tumor development. Our results demonstrate that ALV-J infection increases IL-6 expression in chicken splenocytes, peripheral blood lymphocytes, and vascular endothelial cells. IL-6 production is induced by the ALV-J envelope protein gp85 and capsid protein p27 via PI3K- and NF-κB-mediated signaling. IL-6 in turn induced expression of vascular endothelial growth factor (VEGF)-A and its receptor, VEGFR-2, in vascular endothelial cells and embryonic vascular tissues. Suppression of IL-6 using siRNA inhibited the ALV-J induced VEGF-A and VEGFR-2 expression in vascular endothelial cells, indicating that the ALV-J-induced VEGF-A/VEGFR-2 expression is mediated by IL-6. As VEGF-A and VEGFR-2 are important factors in oncogenesis, our findings suggest that ALV-J hijacks IL-6 to promote tumorigenesis, and indicate that IL-6 could potentially serve as a therapeutic target in ALV-J infections."xsd:string |
http://purl.uniprot.org/citations/27852059 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.13282"xsd:string |
http://purl.uniprot.org/citations/27852059 | http://purl.uniprot.org/core/author | "Gao Y."xsd:string |
http://purl.uniprot.org/citations/27852059 | http://purl.uniprot.org/core/author | "Gao H."xsd:string |
http://purl.uniprot.org/citations/27852059 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
http://purl.uniprot.org/citations/27852059 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
http://purl.uniprot.org/citations/27852059 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
http://purl.uniprot.org/citations/27852059 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
http://purl.uniprot.org/citations/27852059 | http://purl.uniprot.org/core/author | "Qi X."xsd:string |
http://purl.uniprot.org/citations/27852059 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
http://purl.uniprot.org/citations/27852059 | http://purl.uniprot.org/core/author | "Zhang Y.'"xsd:string |
http://purl.uniprot.org/citations/27852059 | http://purl.uniprot.org/core/author | "Yao Y."xsd:string |
http://purl.uniprot.org/citations/27852059 | http://purl.uniprot.org/core/author | "Guan X."xsd:string |
http://purl.uniprot.org/citations/27852059 | http://purl.uniprot.org/core/author | "Nair V."xsd:string |
http://purl.uniprot.org/citations/27852059 | http://purl.uniprot.org/core/author | "Gao Y.'"xsd:string |
http://purl.uniprot.org/citations/27852059 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
http://purl.uniprot.org/citations/27852059 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
http://purl.uniprot.org/citations/27852059 | http://purl.uniprot.org/core/pages | "80275-80287"xsd:string |
http://purl.uniprot.org/citations/27852059 | http://purl.uniprot.org/core/title | "Avian leukosis virus subgroup J induces VEGF expression via NF-kappaB/PI3K-dependent IL-6 production."xsd:string |
http://purl.uniprot.org/citations/27852059 | http://purl.uniprot.org/core/volume | "7"xsd:string |
http://purl.uniprot.org/citations/27852059 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27852059 |
http://purl.uniprot.org/citations/27852059 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27852059 |
http://purl.uniprot.org/uniprot/#_A8VHZ1-mappedCitation-27852059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27852059 |
http://purl.uniprot.org/uniprot/#_A5A8F3-mappedCitation-27852059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27852059 |