| http://purl.uniprot.org/citations/27855782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27855782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27855782 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuromodulators shape neural circuit dynamics. Combining electron microscopy, genetics, transcriptome profiling, calcium imaging, and optogenetics, we discovered a peptidergic neuron that modulates C. elegans motor circuit dynamics. The Six/SO-family homeobox transcription factor UNC-39 governs lineage-specific neurogenesis to give rise to a neuron RID. RID bears the anatomic hallmarks of a specialized endocrine neuron: it harbors near-exclusive dense core vesicles that cluster periodically along the axon, and expresses multiple neuropeptides, including the FMRF-amide-related FLP-14. RID activity increases during forward movement. Ablating RID reduces the sustainability of forward movement, a phenotype partially recapitulated by removing FLP-14. Optogenetic depolarization of RID prolongs forward movement, an effect reduced in the absence of FLP-14. Together, these results establish the role of a neuroendocrine cell RID in sustaining a specific behavioral state in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/27855782 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.19887"xsd:string |
| http://purl.uniprot.org/citations/27855782 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.19887"xsd:string |
| http://purl.uniprot.org/citations/27855782 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/27855782 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/27855782 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/27855782 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/27855782 | http://purl.uniprot.org/core/author | "Meng J."xsd:string |
| http://purl.uniprot.org/citations/27855782 | http://purl.uniprot.org/core/author | "Meng J."xsd:string |
| http://purl.uniprot.org/citations/27855782 | http://purl.uniprot.org/core/author | "Luo L."xsd:string |
| http://purl.uniprot.org/citations/27855782 | http://purl.uniprot.org/core/author | "Luo L."xsd:string |
| http://purl.uniprot.org/citations/27855782 | http://purl.uniprot.org/core/author | "Qu Y."xsd:string |
| http://purl.uniprot.org/citations/27855782 | http://purl.uniprot.org/core/author | "Qu Y."xsd:string |
| http://purl.uniprot.org/citations/27855782 | http://purl.uniprot.org/core/author | "Chitturi J."xsd:string |
| http://purl.uniprot.org/citations/27855782 | http://purl.uniprot.org/core/author | "Chitturi J."xsd:string |
| http://purl.uniprot.org/citations/27855782 | http://purl.uniprot.org/core/author | "Hung W."xsd:string |
| http://purl.uniprot.org/citations/27855782 | http://purl.uniprot.org/core/author | "Hung W."xsd:string |
| http://purl.uniprot.org/citations/27855782 | http://purl.uniprot.org/core/author | "Lim M.A."xsd:string |
| http://purl.uniprot.org/citations/27855782 | http://purl.uniprot.org/core/author | "Lim M.A."xsd:string |
| http://purl.uniprot.org/citations/27855782 | http://purl.uniprot.org/core/author | "Zhen M."xsd:string |
| http://purl.uniprot.org/citations/27855782 | http://purl.uniprot.org/core/author | "Zhen M."xsd:string |
| http://purl.uniprot.org/citations/27855782 | http://purl.uniprot.org/core/author | "Schnabel R."xsd:string |
| http://purl.uniprot.org/citations/27855782 | http://purl.uniprot.org/core/author | "Schnabel R."xsd:string |