| http://purl.uniprot.org/citations/27859042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27859042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27859042 | http://www.w3.org/2000/01/rdf-schema#comment | "Establishing and maintaining maternal-fetal tolerance is essential for a successful pregnancy; failure of immunological adaptation to pregnancy leads to severe complications such as abortion or preterm delivery. Myeloid-derived suppressor cells (MDSCs) are innate immune cells that suppress T-cell responses, expand during pregnancy and thus may play a role in tolerance induction. Human leucocyte antigen G (HLA-G) is a major histocompatibility complex (MHC) I molecule with immune-modulatory properties, which is expressed during pregnancy. Here, we investigated the impact of HLA-G on MDSCs accumulation and activation in pregnant women. We demonstrate that granulocytic MDSCs (GR-MDSCs) express receptors for HLA-G, namely immunoglobulin-like transcript (ILT) 2 and 4, and that ILT4-expression by GR-MDSCs is regulated during pregnancy. Stimulation with soluble HLA-G (sHLA-G) increased suppressive activity of GR-MDSCs, induced MDSCs from peripheral blood mononuclear cells (PBMCs) and led to phosphorylation of the signal transducer and activator of transcription 3 (STAT3) and induction of indoleamine-2,3-dioxygenase (IDO) in myeloid cells. Effects of sHLA-G on MDSC accumulation were mediated through ILT4. These results suggest an interaction between MDSCs and HLA-G in humans as a potential mechanism for maintaining maternal-fetal tolerance. Modulating MDSC function during pregnancy via HLA-G might provide new opportunities for a therapeutic manipulation of immunological pregnancy complications."xsd:string |
| http://purl.uniprot.org/citations/27859042 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201646564"xsd:string |
| http://purl.uniprot.org/citations/27859042 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201646564"xsd:string |
| http://purl.uniprot.org/citations/27859042 | http://purl.uniprot.org/core/author | "Schwarz J."xsd:string |
| http://purl.uniprot.org/citations/27859042 | http://purl.uniprot.org/core/author | "Schwarz J."xsd:string |
| http://purl.uniprot.org/citations/27859042 | http://purl.uniprot.org/core/author | "Gille C."xsd:string |
| http://purl.uniprot.org/citations/27859042 | http://purl.uniprot.org/core/author | "Gille C."xsd:string |
| http://purl.uniprot.org/citations/27859042 | http://purl.uniprot.org/core/author | "Koestlin N."xsd:string |
| http://purl.uniprot.org/citations/27859042 | http://purl.uniprot.org/core/author | "Koestlin N."xsd:string |
| http://purl.uniprot.org/citations/27859042 | http://purl.uniprot.org/core/author | "Marme A."xsd:string |
| http://purl.uniprot.org/citations/27859042 | http://purl.uniprot.org/core/author | "Marme A."xsd:string |
| http://purl.uniprot.org/citations/27859042 | http://purl.uniprot.org/core/author | "Ostermeir A.L."xsd:string |
| http://purl.uniprot.org/citations/27859042 | http://purl.uniprot.org/core/author | "Ostermeir A.L."xsd:string |
| http://purl.uniprot.org/citations/27859042 | http://purl.uniprot.org/core/author | "Poets C.F."xsd:string |
| http://purl.uniprot.org/citations/27859042 | http://purl.uniprot.org/core/author | "Poets C.F."xsd:string |
| http://purl.uniprot.org/citations/27859042 | http://purl.uniprot.org/core/author | "Spring B."xsd:string |
| http://purl.uniprot.org/citations/27859042 | http://purl.uniprot.org/core/author | "Spring B."xsd:string |
| http://purl.uniprot.org/citations/27859042 | http://purl.uniprot.org/core/author | "Walter C.B."xsd:string |
| http://purl.uniprot.org/citations/27859042 | http://purl.uniprot.org/core/author | "Walter C.B."xsd:string |
| http://purl.uniprot.org/citations/27859042 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27859042 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27859042 | http://purl.uniprot.org/core/name | "Eur. J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/27859042 | http://purl.uniprot.org/core/name | "Eur. J. Immunol."xsd:string |