| http://purl.uniprot.org/citations/27862137 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27862137 | http://www.w3.org/2000/01/rdf-schema#comment | "Mycobacterium tuberculosis (Mtb) is particularly challenging for the immune system being an intracellular pathogen, and a variety of T cell subpopulations are activated by the host defence mechanism. In this study, we investigated T cell responses and regulation in active TB patients with drug-sensitive Mtb (N = 18) during 24 weeks of efficient anti-TB therapy. T cell activation, differentiation, regulatory T cell (Treg) subsets, Mtb-induced T cell proliferation and in vitro IL-10 and TGF-β modulation were analysed by flow cytometry at baseline and after 8 and 24 weeks of therapy, while soluble cytokines in culture supernatants were analysed by a 9-plex Luminex assay. Successful treatment resulted in significantly reduced co-expression of HLA-DR/CD38 and PD-1/CD38 on both CD4+ and CD8+ T cells, while the fraction of CD4+ CD25high CD127low Tregs (P = 0.017) and CD4+ CD25high CD127low CD147+ Tregs (P = 0.029) showed significant transient increase at week 8. In vitro blockade of IL-10/TGF-β upon Mtb antigen stimulation significantly lowered the fraction of ESAT-6-specific CD4+ CD25high CD127low Tregs at baseline (P = 0.047), while T cell proliferation and cytokine production were unaffected. Phenotypical and Mtb-specific T cell signatures may serve as markers of effective therapy, while the IL-10/TGF-β pathway could be a target for early inhibition to facilitate Mtb clearance. However, larger clinical studies are needed for verification before concluding."xsd:string |
| http://purl.uniprot.org/citations/27862137 | http://purl.org/dc/terms/identifier | "doi:10.1111/sji.12511"xsd:string |
| http://purl.uniprot.org/citations/27862137 | http://purl.uniprot.org/core/author | "Kvale D."xsd:string |
| http://purl.uniprot.org/citations/27862137 | http://purl.uniprot.org/core/author | "Dyrhol-Riise A.M."xsd:string |
| http://purl.uniprot.org/citations/27862137 | http://purl.uniprot.org/core/author | "Feruglio S.L."xsd:string |
| http://purl.uniprot.org/citations/27862137 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27862137 | http://purl.uniprot.org/core/name | "Scand J Immunol"xsd:string |
| http://purl.uniprot.org/citations/27862137 | http://purl.uniprot.org/core/pages | "138-146"xsd:string |
| http://purl.uniprot.org/citations/27862137 | http://purl.uniprot.org/core/title | "T Cell Responses and Regulation and the Impact of In Vitro IL-10 and TGF-beta Modulation During Treatment of Active Tuberculosis."xsd:string |
| http://purl.uniprot.org/citations/27862137 | http://purl.uniprot.org/core/volume | "85"xsd:string |
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