| http://purl.uniprot.org/citations/27862269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27862269 | http://www.w3.org/2000/01/rdf-schema#comment | "Secretory defects cause transcriptional repression of ribosome biogenesis in Saccharomyces cerevisiae. However, the molecular mechanism underlying secretory defect-induced transcriptional repression of ribosome biogenesis remains to be fully elucidated. In this study, we demonstrated that the Arp2/3 complex was required for reduction of ribosome protein gene expression in response to defective secretion by addition of tunicamycin. Two cmd1 mutants, cmd1-228 and cmd1-239 that cause mislocalization of calmodulin and defective mitotic spindle formation, respectively, failed to interact with Arc35, a component of the Arp2/3 complex. These mutants also caused defects in the reduction of ribosome protein gene expression induced by secretory blockade. A mutation in TUB4 (tub4-1), whose product has an essential function in microtubule organization, showed a similar response. In addition, we showed that the response to a secretory defect required SUN protein Mps3, which was localized at the nuclear envelope and involved in spindle pole body assembly. These results suggest that the Arp2/3 complex is required to transmit signals resulting from secretory blockade, and that the spindle pole body functions as a transit point from cytoplasm to Mps3 at the nuclear envelope. Copyright © 2016 John Wiley & Sons, Ltd."xsd:string |
| http://purl.uniprot.org/citations/27862269 | http://purl.org/dc/terms/identifier | "doi:10.1002/yea.3221"xsd:string |
| http://purl.uniprot.org/citations/27862269 | http://purl.uniprot.org/core/author | "Katayama M."xsd:string |
| http://purl.uniprot.org/citations/27862269 | http://purl.uniprot.org/core/author | "Sakamoto A."xsd:string |
| http://purl.uniprot.org/citations/27862269 | http://purl.uniprot.org/core/author | "Mizuta K."xsd:string |
| http://purl.uniprot.org/citations/27862269 | http://purl.uniprot.org/core/author | "Funato K."xsd:string |
| http://purl.uniprot.org/citations/27862269 | http://purl.uniprot.org/core/author | "Kodama Y."xsd:string |
| http://purl.uniprot.org/citations/27862269 | http://purl.uniprot.org/core/author | "Yabuki Y."xsd:string |
| http://purl.uniprot.org/citations/27862269 | http://purl.uniprot.org/core/author | "Yatsuhashi A."xsd:string |
| http://purl.uniprot.org/citations/27862269 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27862269 | http://purl.uniprot.org/core/name | "Yeast"xsd:string |
| http://purl.uniprot.org/citations/27862269 | http://purl.uniprot.org/core/pages | "155-163"xsd:string |
| http://purl.uniprot.org/citations/27862269 | http://purl.uniprot.org/core/title | "Arp2/3 complex and Mps3 are required for regulation of ribosome biosynthesis in the secretory stress response."xsd:string |
| http://purl.uniprot.org/citations/27862269 | http://purl.uniprot.org/core/volume | "34"xsd:string |
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