| http://purl.uniprot.org/citations/27864060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27864060 | http://www.w3.org/2000/01/rdf-schema#comment | "JNK proteins are conserved stress-activated MAP kinases. In C. elegans, the JNK-homolog KGB-1 plays essential roles in protection from heavy metals and protein folding stress. However, the contributions of KGB-1 are age-dependent, providing protection in larvae, but reducing stress resistance and shortening lifespan in adults. Attenuation of DAF-16 was linked to the detrimental contributions of KGB-1 in adults, but its involvement in KGB-1-dependent protection in larvae remains unclear. To characterize age-dependent contributions of KGB-1, we used microarray analysis to measure gene expression following KGB-1 activation either in developing larvae or in adults, achieved by knocking down its negative phosphatase regulator vhp-1. This revealed a robust KGB-1 regulon, most of which consisting of genes induced following KGB-1 activation regardless of age; a smaller number of genes was regulated in an age-dependent manner. We found that the bZIP transcription factor FOS-1 was essential for age-invariant KGB-1-dependent gene induction, but not for age-dependent expression. The latter was more affected by DAF-16, which was further found to be required for KGB-1-dependent cadmium resistance in larvae. Our results identify FOS-1 as a transcriptional activator mediating age-invariant contributions of KGB-1, including a regulatory loop of KGB-1 signaling, but also stress the importance of DAF-16 as a mediator of age-dependent contributions."xsd:string |
| http://purl.uniprot.org/citations/27864060 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2016.11.010"xsd:string |
| http://purl.uniprot.org/citations/27864060 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/27864060 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/27864060 | http://purl.uniprot.org/core/author | "Shapira M."xsd:string |
| http://purl.uniprot.org/citations/27864060 | http://purl.uniprot.org/core/author | "Twumasi-Boateng K."xsd:string |
| http://purl.uniprot.org/citations/27864060 | http://purl.uniprot.org/core/author | "Block D.H."xsd:string |
| http://purl.uniprot.org/citations/27864060 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27864060 | http://purl.uniprot.org/core/name | "Cell Signal"xsd:string |
| http://purl.uniprot.org/citations/27864060 | http://purl.uniprot.org/core/pages | "1-8"xsd:string |
| http://purl.uniprot.org/citations/27864060 | http://purl.uniprot.org/core/title | "FOS-1 functions as a transcriptional activator downstream of the C. elegans JNK homolog KGB-1."xsd:string |
| http://purl.uniprot.org/citations/27864060 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/27864060 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27864060 |
| http://purl.uniprot.org/citations/27864060 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27864060 |
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| http://purl.uniprot.org/uniprot/#_O44408-mappedCitation-27864060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27864060 |
| http://purl.uniprot.org/uniprot/O44408 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27864060 |
| http://purl.uniprot.org/uniprot/G5ECG2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/27864060 |