| http://purl.uniprot.org/citations/27864146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/27864146 | http://www.w3.org/2000/01/rdf-schema#comment | "Aberrant expression of microRNAs contributes to the initiation and progression of numerous human cancers. The underlying effects and molecular mechanisms of microRNA-187 (miR-187) in gastric cancer (GC) remain unclear. The present study reports that miR-187 was significantly overexpressed in GC tissues compared to that in non-tumor tissues and was associated with malignant clinical factors such as depth of invasion (P = 0.005), tumor size (P = 0.024), lymph node metastasis (P = 0.048), and TNM stage (P = 0.035). Additionally, miR-187 promoted tumor growth in vivo, and significantly increased migration, invasion, and proliferation, but inhibited apoptosis in GC cells. It was found that collapsin response mediator protein 1 (CRMP1), a tumor suppressor, was a direct downstream target of miR-187 in GC. Furthermore, CRMP1 silencing resulted in similar effects on cell proliferation, migration, and apoptosis as those of miR-187 overexpressing GC cells. Additionally, the effects of miR-187 inhibitor on cell migration and cell apoptosis were reversed by CRMP1 downregulation. In summary, miR-187 promotes tumor progression by regulating CRMP1 expression in GC and may thus be a potential prognostic marker and a therapeutic target in GC."xsd:string |
| http://purl.uniprot.org/citations/27864146 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2016.11.079"xsd:string |
| http://purl.uniprot.org/citations/27864146 | http://purl.uniprot.org/core/author | "Fu Y."xsd:string |
| http://purl.uniprot.org/citations/27864146 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/27864146 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/27864146 | http://purl.uniprot.org/core/author | "Ren L."xsd:string |
| http://purl.uniprot.org/citations/27864146 | http://purl.uniprot.org/core/author | "Sun Q."xsd:string |
| http://purl.uniprot.org/citations/27864146 | http://purl.uniprot.org/core/author | "Du X."xsd:string |
| http://purl.uniprot.org/citations/27864146 | http://purl.uniprot.org/core/author | "Xiao G."xsd:string |
| http://purl.uniprot.org/citations/27864146 | http://purl.uniprot.org/core/author | "Ren D."xsd:string |
| http://purl.uniprot.org/citations/27864146 | http://purl.uniprot.org/core/author | "Hui Y."xsd:string |
| http://purl.uniprot.org/citations/27864146 | http://purl.uniprot.org/core/author | "Di M."xsd:string |
| http://purl.uniprot.org/citations/27864146 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/27864146 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/27864146 | http://purl.uniprot.org/core/pages | "597-603"xsd:string |
| http://purl.uniprot.org/citations/27864146 | http://purl.uniprot.org/core/title | "MicroRNA-187 regulates gastric cancer progression by targeting the tumor suppressor CRMP1."xsd:string |
| http://purl.uniprot.org/citations/27864146 | http://purl.uniprot.org/core/volume | "482"xsd:string |
| http://purl.uniprot.org/citations/27864146 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/27864146 |
| http://purl.uniprot.org/citations/27864146 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/27864146 |
| http://purl.uniprot.org/uniprot/#_E9PD68-mappedCitation-27864146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27864146 |
| http://purl.uniprot.org/uniprot/#_Q14194-mappedCitation-27864146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27864146 |
| http://purl.uniprot.org/uniprot/#_B3KT07-mappedCitation-27864146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27864146 |
| http://purl.uniprot.org/uniprot/#_B3KV96-mappedCitation-27864146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27864146 |
| http://purl.uniprot.org/uniprot/#_B3KXQ5-mappedCitation-27864146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/27864146 |